Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy

Nazif, Hayam K.; Shatla, Rania H.; Elsayed, Riad M; Tawfik, Eman A.; Osman, Noha Mohamed; Korra, S; Ibrahim, Ahmad

doi:10.1007/s00381-017-3346-9

Cited by 12 publications

(5 citation statements)

References 27 publications

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“…Although we previously showed evidence supporting cognitive impairment in individuals with CP that is comparable to those observed in the older adult population with MCI ( 2 ), biological determinants of cognitive decline in adults with CP are still in scarcity ( 2 , 25 ). Despite a previous study examining the roles of circulating IGF-1 in bone mineral density in young adults with CP ( 19 , 26 ), no studies have associated circulating IGF-1 with cognition in adults with CP. Whether circulating IGF-1 is a biological determinant of cognitive aging in adults with CP is thus unknown.…”

Section: Introductionmentioning

confidence: 94%

Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study

Heyn

Tagawa

et al. 2022

Front. Neurol.

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ObjectiveAdults with cerebral palsy (CP) often have impaired cognitive functions. CP also has deteriorations in multiple quality-of-life (QoL) domains. The bio-psycho-social health psychology model posits that biological factor interacts with social and psychological functions. However, the biological determinant of psycho-social and functional outcomes in CP has been scarcely examined. Circulating Insulin-like growth factor-1 (IGF-1) is associated with cognitive deficits in older adults, we thus aimed to examine the associations of circulating IGF-1 with: (1) objectively measured cognitive functions, (2) self-reported cognitive functions, and (3) QoL measures in adults diagnosed with CP.MethodsSeventy-two adults with CP and varying degrees of cognitive functions were recruited from an accredited clinical motion analysis laboratory at a regional Children's Hospital. Circulating IGF-1 was measured using post-fasting serum. The Wechsler Adult Intelligence Scale (WAIS) tests were administered to assess multiple cognitive functions, whereas the Patient-Reported Outcomes Measurement Information System (PROMIS) was used to measure multiple domains of self-reported health, including cognitive complaints and eight QoL domains.ResultsSixty-eight participants had complete data [mean age = 25 (SD = 5.3), female = 52.8%]. Controlling for covariates, circulating IGF-1 was associated with multiple cognitive domains, including positively with declarative memory and executive function and inversely with visual-spatial and motor skills, and processing speed, while no association with subjective memory complaint was detected. Circulating IGF-1 was also inversely associated with four QoL domains, including depressive symptoms, executive function, physical function, and social roles and activities.ConclusionsIn CP, circulating IGF-1 might be a useful biological determinant of objective cognitive functions and several quality-of-life domains commonly impaired in CP.

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Section: Introductionmentioning

confidence: 94%

Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study

Heyn

Tagawa

et al. 2022

Front. Neurol.

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“…BMD was significantly decreased in children with spastic CP compared to healthy children and was associated with low circulating IGF-1 levels, severe GMFCS level, and use of anticonvulsive drugs. Children with CP also exhibited increased fracture risk (Nazif et al, 2017).…”

Section: Cerebral Palsymentioning

confidence: 99%

Effects of Neurological Disorders on Bone Health

2020

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Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.

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“…Although a recent review compares the scientific works about the interaction between vitamin D and GH disorders (mainly GHD and acromegaly) on populations of adults and children [65–71], there is currently no review that has collected together the clinical works that compare more generally vitamin D and the GH/IGF axis. A PubMed research for MEDLINE filtered for pediatric age (0–18 year-old subjects) was undertaken by using the following terms as key words: “Vitamin D” and “Growth”, “Growth Hormone” or “GH”, “Insulin-like Growth Factor-1” or “IGF-1”, and “Growth Hormone Deficiency” or “GHD”.…”

Section: Vitamin D Metabolism and Gh In Clinical Pediatric Studiesmentioning

confidence: 99%

“…Among these two biochemical parameters, the authors also found a direct correlation that strengthens the idea of an IGF-1/vitamin D axis with mutual influences. This could also explain the osteopenia that characterizes patients with CP [71].…”

Section: Vitamin D Metabolism and Gh In Clinical Pediatric Studiesmentioning

confidence: 99%

Vitamin D and growth hormone in children: a review of the current scientific knowledge

et al. 2019

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BackgroundHuman growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). In contrast, vitamin D is involved in the processes of bone growth and mineralization through the regulation of calcium and phosphorus metabolism. Nevertheless, no scientific study has yet elucidated how they interact with one another, especially as a dysfunction in which one influences the other, even if numerous biochemical and clinical studies confirm the presence of a close relationship.Main bodyWe reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.ConclusionsThese results could be followed by preventive interventions aimed at reducing the vitamin D deficit in pediatric age. In addition, further research is needed to fully understand how vitamin D and growth are intertwined.

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Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy

Cited by 12 publications

References 27 publications

Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study

Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study

Effects of Neurological Disorders on Bone Health

Vitamin D and growth hormone in children: a review of the current scientific knowledge

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