Bone Mineral Density and its Related Factors in Elderly Male Chinese Patients with Type 2 Diabetes

Xu, Lei; Cheng, Minna; Liu, Xiangqun; Shan, Peiyan; Gao, Haiqing

doi:10.1016/j.arcmed.2006.10.003

Cited by 15 publications

(12 citation statements)

References 42 publications

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“…The third study assessed BMD measured by DXA in 131 elderly T2DM males in China. The findings from this study also suggested that decreased BMD and poor glycemic control were correlated with osteoporosis 103. In contrast, Bridges et al assessed the BMD in 35 and 90 men with T1DM and T2DM, respectively, compared to 50 control subjects.…”

Section: Resultsmentioning

confidence: 49%

Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?

Abdulameer¹,

Sulaiman²,

Hassali³

et al. 2012

PPA

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Diabetes mellitus (DM) is a pandemic and chronic metabolic disorder with substantial morbidity and mortality. In addition, osteoporosis (OP) is a silent disease with a harmful impact on morbidity and mortality. Therefore, this systematic review focuses on the relationship between OP and type 2 diabetes mellitus (T2DM). Systematic reviews of full-length articles published in English from January 1950 to October 2010 were identified in PubMed and other available electronic databases on the Universiti Sains Malaysia Library Database. The following keywords were used for the search: T2DM, OP, bone mass, skeletal. Studies of more than 50 patients with T2DM were included. Forty-seven studies were identified. The majority of articles (26) showed increased bone mineral density (BMD), while 13 articles revealed decreased BMD; moreover, eight articles revealed normal or no difference in bone mass. There were conflicting results concerning the influence of T2DM on BMD in association with gender, glycemic control, and body mass index. However, patients with T2DM display an increased fracture risk despite a higher BMD, which is mainly attributable to the increased risk of falling. As a conclusion, screening, identification, and prevention of potential risk factors for OP in T2DM patients are crucial and important in terms of preserving a good quality of life in diabetic patients and decreasing the risk of fracture. Patients with T2DM may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls. Patient education about an adequate calcium and vitamin D intake and regular exercise is important for improving muscle strength and balance. Furthermore, adequate glycemic control and the prevention of diabetic complications are the starting point of therapy in diabetic patients.

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Section: Resultsmentioning

confidence: 49%

Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?

Abdulameer¹,

Sulaiman²,

Hassali³

et al. 2012

PPA

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show abstract

“…Interestingly, a high BMI is associated with increased BMD and has been shown to be a protective factor against the risk of osteoporosis and fracture in some studies [25–27]. However, Xu et al [14] reported a positive correlation between weight as well as BMI with BMD in Chinese male patients with T2DM. The results of this study are in agreement with results of a meta-analysis that found that BMI as a predictor of BMD also holds true in patients with T2DM [28].…”

Section: Discussionmentioning

confidence: 99%

“…Because few studies have assessed the prevalence of osteoporosis in old male Chinese patients with T2DM [14, 15], the present study sought to investigate osteoporosis prevalence, assess levels of bone metabolism markers, and evaluate risk factors for low BMD. Because the effects of T2DM on bone metabolism are less clear in old men with T2DM, identifying causative factors and/or markers of osteoporosis beyond BMD analysis may contribute to its prevention and intervention in this population.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Osteoporosis and Its Associated Factors among Older Men with Type 2 Diabetes

Chen

Deng

2013

International Journal of Endocrinology

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This study investigated the prevalence of osteoporosis and its associated factors in old men with T2DM to identify risk factors for low BMD. We enrolled 93 old men (≥60 years of age) with T2DM and 125 healthy old men (controls) and collected data of their lifestyle, medical history, bone densitometry, body weight, height, and blood pressure. Blood samples were collected for biochemical analyses. Urine samples were collected to determine 24 h urinary creatinine, albumin, and protein. Although no differences in age, blood pressure, waist-to-hip ratio, body mass index (BMI), and testosterone levels were observed, the prevalence of low BMD was significantly higher in the T2DM group compared to the control group. The risk of developing low BMD and fracture in T2DM subjects was increased by 46- and 26-fold, respectively, compared to control subjects. BMD of total spine and hip was positively correlated with BMI and negatively correlated with age, duration of diabetes, creatinine, and 24 h urinary albumin. So old men with T2DM have a greater risk of developing low BMD than old men without T2DM.

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“…All but one of the studies was conducted in Western countries, characterized by a high prevalence of obesity and overweight in patients with type 2 diabetes. Studies in East Asian countries, with a lower prevalence of obesity in diabetic patients, have provided inconsistent results, reporting lower [47][48][49], similar [50][51][52][53] and higher [50][51][52]54,55] BMD at the hip and/ or spine in those with diabetes. Two studies in China have assessed the relationship between DM and BMD, stratified by BMI.…”

Section: Bone Density Is Higher With Diabetesmentioning

confidence: 99%