Bone mineral density and risk of postmenopausal breast cancer

Grenier, Debjani; Cooke, Andrew; Lix, Lisa M.; Metge, Colleen; Lu, Huimin; Leslie, William D.

doi:10.1007/s10549-010-1138-y

Cited by 30 publications

(31 citation statements)

References 28 publications

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“…The study revealed an increased breast cancer risk for the third and fourth quartiles of lumbar spine BMD and for the third quartile for femoral neck BMD after adjusting for age and HRT use [10].…”

Section: Discussionmentioning

confidence: 88%

“…The majority of the reports originate from large databases such as the Rotterdam [6], Women’s Health Initiative (WHI) [5] and Framingham [16] studies or from pivotal trials in the field of osteoporosis (SOF, FIT, DOES) [2], [7], [9], that integrated data on BMD and breast cancer incidence in the same patient (2,4–7,9). Other studies supporting the association of higher BMD with greater risk of breast cancer derived from local BMD registries that were related to breast cancer registries in the same area [8], [10]. In some of these reports BMD was shown to be associated with increased breast cancer risk after adjusting for variables representing life-time estrogen exposure (lifetime ovulation period, BMI etc.)…”

Section: Discussionmentioning

confidence: 99%

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Association between Bone Mineral Density and Incidence of Breast Cancer

et al. 2013

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IntroductionPrevious studies have suggested an inverse relationship between bone mineral density (BMD) and breast cancer incidence. The primary objective of this study was to assess whether BMD is associated with risk of subsequent breast cancer occurrence in the female population of southern Israel.MethodsThe electronic medical charts of women who underwent BMD at the Soroka Medical Center (SMC) between February 2003 and March 2011 were screened for subsequent breast cancer diagnoses. Women were divided by tertiles of BMD at 3 skeletal sites: lumbar spine (LS, L1–4), total hip (TH) and femoral neck (FN). The incidence of breast cancer was calculated.ResultsOf 15268 women who underwent BMD testing, 86 were subsequently diagnosed with breast cancer. Most women in the study were older than 50 years (94.2% and 92.7%, respectively; p = 0.597). Women who subsequently developed breast cancer had a higher mean body-mass index (BMI) (30.9±5.5 vs. 29.1±5.7 p = 0.004) and the mean BMD Z-score was significantly higher than in those without breast cancer for all 3 skeletal sites (LS: 0.36±1.58 vs. −0.12±1.42, p = 0.002; TH: 0.37±1.08 vs. 0.03±1.02, p = 0.002; FN: 0.04±0.99 vs. −0.18±0.94; p = 0.026). Women in the highest Z-score tertiles at the FN and TH had a higher chance of developing breast cancer compared to the lowest tertile; odds ratio of 2.15, 2.02, respectively (P = 0.004 and 0.01 respectively). No association was found between the BMD Z-score and the stage, histology, grade or survival from breast cancer.ConclusionsThis study provides additional support for an inverse association between BMD and the risk of breast cancer.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Association between Bone Mineral Density and Incidence of Breast Cancer

et al. 2013

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“…Bone density may be a marker of cumulative estrogen exposure, and studies have reported positive associations between bone density and postmenopausal breast cancer risk [2, 3]. …”

Section: Introductionmentioning

confidence: 99%

Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States

et al. 2012

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“…On the other hand, no correlation was demonstrated in studies that analyzed the BMD-breast cancer relationship in premenopausal women (7,18). Therefore, we did not enroll premenopausal patients in the study.…”

Section: Discussionmentioning

confidence: 98%

The Relationship between Bone Mineral Density and Estrogen Receptor Positivity in Patients with Breast Cancer

İyigün¹,

Pilancı²,

Çabuk³

et al. 2016

J Breasth Health

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IntroductionBreast cancer is the most prevalent cancer type and the second leading cause of death in women (1). Advanced age, early menarche, firstterm pregnancy at a late age, late menopause, and long-term hormone replacement treatment are among the risk factors for breast cancer (2-4). The relationship between these risk factors and breast cancer are reported to be due to the estrogen-induced increase in mitotic activity in breast tissue, which results in mutations (5).Estrogen hormone is an important risk factor for breast cancer; however, serum levels often vary, which obstructs correlating serum estrogen levels with the risk of breast cancer (6). Serum samples are not sufficient alone to diagnose breast cancer or identify the long-term estrogen level of tissues. Bone mineral density (BMD) should be considered a good indicator of tissue levels of estrogen because BMD elevates in parallel with the increase in estrogen level (7). Estrogen lessens bone destruction while amplifying bone volume and bone mineral density. When we consider this information, we may think that there is a correlation between BMD and breast cancer. Nevertheless, studies that investigated the relationship between bone mineral density and development of breast cancer revealed contradictory results (8-11).In patients with breast cancer, the ratio of tumor estrogen receptor (ER) positivity enhances with age. In a study carried out on Turkish women, ER was found positive in 66% of pre-menopausal women, and this rate increased to 73% in menopausal women (12). Only a few studies in the literature have shown a link of the change in ER positivity with bone density, but none were conducted in Turkey.The objective of this study was to compare the BMD of postmenopausal women with breast cancer with that of control subjects and thus to investigate the association between tumor estrogen receptor level and bone mineral density. J Breast Health 2016; 12: 119-22 DOI: 10.5152/tjbh.2016 12: 119-22 DOI: 10.5152/tjbh. .2961 119 ABSTRACT Objective: The effect of estrogen on bone mineral density (BMD) and breast cancer has been known for a long time. The aim of this study was to compare of the BMD of patients with breast cancer and healthy individuals, and to investigate the degree of correlation of estrogen receptor (ER) with BMD. Materials and Methods: Seventy-one patients with postmenopausal breast cancer and 79 healthy dividuals were included in the study. The patient demographics (age, menopause age, body mass index, number of children, BMD, Z scores, and estrogen status for breast cancer patients) were taken from hospital records. Results: No significant difference was detected between the case and control groups in lumbar region Z scores (p=0.074). At the femur neck, the control group Z scores was higher than patient group (p=0.002). BMI was higher in the patients with breast cancer (p=0.001). There was no statistically significant correlation between ER positivity, BMD, and BMI in ER-positive patients (p=0.495, p=0.8, p=0.846, respectively). There ...

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Bone mineral density and risk of postmenopausal breast cancer

Cited by 30 publications

References 28 publications

Association between Bone Mineral Density and Incidence of Breast Cancer

Association between Bone Mineral Density and Incidence of Breast Cancer

Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States

The Relationship between Bone Mineral Density and Estrogen Receptor Positivity in Patients with Breast Cancer

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