Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Yang, Chan Joo; Kim, Yehree; Lee, Hwan Seo; Park, Hong Ju

doi:10.3233/ves-170625

Cited by 52 publications

(52 citation statements)

References 37 publications

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“…Only age is an independent predictor of recurrence, although a low BMD and age correlate with the recurrence of BPPV. 25 Similar findings regarding gender and age were observed in our study, since there was a statistically significant difference in the amount of vitamin D, age, and gender in the BPPV group.…”

Section: Discussionsupporting

confidence: 89%

“…The 25-OH-vitamin D dosages were performed in serum samples by fully automated chemiluminescent method (Architect iSR2000-Abbott). They were adopted according to 25 20,21 The BMD was evaluated with the QDR 4500 duo-energy densitometer (Hologic Inc., Bedford, MA, USA) in the lumbar spine (L1-L4), femoral neck and total femur regions. For the analysis, we used the criteria of the World Health Organization, 22 normal BMD with T-score up to À1.0 AE standard deviation (SD), osteopenia with T-score between À1.0 to À2.4 AE SD, and osteoporosis with T-score À2.5 AE SD at any bone site.…”

Section: Clinical Evaluationmentioning

confidence: 99%

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Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Bazoni

Ciquinato

Marquez

et al. 2019

Int Arch Otorhinolaryngol

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Introduction Studies have found that elderly patients with benign paroxysmal positional vertigo (BPPV) may present low levels of vitamin D (25 (OH) D), changes in bone mineral density, and diabetes mellitus (DM). Objective: To investigate the possible association between BPPV, bone mineral density, hypovitaminosis D, 25 (OH) D and DM. Methods The sample consisted of 109 elderly subjects. The BPPV was verified by a standardized questionnaire and the Dix-Hallpike maneuver. Blood samples were collected for the investigation of 25 (OH) D serum levels. The bone mineral density was evaluated by means of a densitometer. Diabetes mellitus verification was performed using a self-reported questionnaire. Results Of the 109 participants, 17 had BPPV. There was a statistically significant difference between BPPV and gender (p = 0.027, phi = 0.222), with female representing 88.2% of those with BPPV. In the group with BPPV, there was a statistically significant difference for the amount of vitamin D found (p = 0.001) and for age (p = 0.001). In the elderly group with DM and BPPV, a difference was found for the standard deviation of the femur (p = 0.022) with posthoc Dunn, identifying the difference between diabetics with and without BPPV (p = 0.047). Conclusion Although no association was found (25 (OH) D levels) with BPPV in the general population of this study, it was observed that there was an association with bone mineral density in the elderly group with DM and BPPV, and, in the group with BPPV, there was an association between the amount of vitamin D and age.

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Section: Discussionsupporting

confidence: 89%

Section: Clinical Evaluationmentioning

confidence: 99%

Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Bazoni

Ciquinato

Marquez

et al. 2019

Int Arch Otorhinolaryngol

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“… 32 , 41 A large population-based study including 6,649 patients with osteoporosis and 26,596 matched controls demonstrated that the risk of manifesting BPPV in patients with osteoporosis was a 1.82-fold higher than in the controls. 42 A usual cause of disorders in the metabolism of calcium is the deficiency of vitamin D. Yang et al 43 evaluated the relationship between bone mineral density and 25-hydroxyvitamin D with the presence and recurrence of BPPV. The authors found that low bone mineral density in women and low serum 25-hydroxyvitamin D levels in men were significantly associated with the recurrence of BPPV, whereas age was an independent predictor of recurrence.…”

Section: Etiologymentioning

confidence: 99%

Benign paroxysmal positional vertigo in the elderly: current insights

Balatsouras

Koukoutsis

Fassolis

et al. 2018

CIA

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Balance disorders, unsteadiness, dizziness and vertigo in the elderly are a significant health problem, needing appropriate treatment. One third of elderly patients with vertigo were diagnosed with benign paroxysmal positional vertigo (BPPV), the most common cause of dizziness in both primary care specialist Neurology and Ear Nose Throat settings. BPPV presents a specific paroxysmal positional nystagmus which can be obtained using the appropriate diagnostic positional test and can be treated effectively using specific therapeutic maneuvers. This review presents current insights into the diagnostic, pathogenetic and therapeutic aspects of BPPV in the elderly. BPPV in older patients does not differ significantly from BPPV in younger patients, with regard to pathogenesis, diagnosis and treatment. However, in older patients, its prevalence is higher and it responds less effectively to treatment, having a tendency for recurrence. Specific issues which should be considered in the elderly are: 1) difficulty in obtaining an accurate history; 2) difficulty in performing the diagnostic and therapeutic maneuvers, which should be executed with slow and gentle movements and extremely cautiously to avoid any vascular or orthopedic complications; and 3) the relation between BPPV and falls.

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“…reported that serum 25(OH) D levels were lower in 37 male patients with BPPV than in controls. While, a retrospective study including 30 male patients with BPPV revealed that serum 25(OH) D concentrations were significantly decreased compared with controls, whereas BMD results showed no significant differences ( 12 ). Different from previous findings, there were no significant differences in mean T-scores and vitamin D levels, osteoporosis, and vitamin D deficiency prevalence between 29 male BPPV patients and controls ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the high incidence of BPPV in women, most previous studies selected women as study subjects. Thus, there are few reports assessing BMD and serum levels of 25-hydroxyvitamin D(25(OH) D) in male idiopathic BPPV patients, and the conclusions of these papers are contradictory( 7 , 9 , 12 , 19 , 20 ). Moreover, none of these studies examined biochemical bone turnover markers (BTM) in male idiopathic BPPV patients.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo

Fan

Jin

et al. 2018

Front. Neurol.

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Objective: Several studies have suggested a probable association between benign paroxysmal positional vertigo (BPPV) and both reduction of bone mineral density (BMD) and serum vitamin D levels, but none of these studies have explored their findings by examining bone turnover markers (BTM) in male idiopathic BPPV patients. This study aimed to evaluate the relationship between BMD and serum 25-hydroxyvitamin D (25(OH) D), with the occurrence of BPPV along with the characteristics of bone metabolism in male idiopathic BPPV patients.Methods: This retrospective study comprised 60 male idiopathic BPPV patients and 92 age-matched healthy controls referred to Ningbo No.2 Hospital during the period of February 2016 to February 2018. All subjects' serum levels of 25(OH) D, bone formation marker amino-terminal propeptide of type I procollagen (PINP), and bone resorption marker β-isomerized carboxy-terminal telopeptide of type I collagen (β-CTX) were measured. BMD was determined by dual energy X-ray absorption at the lumbar spine and hip.Results: Among male patients with BPPV, the prevalence of BMD reduction was 35.0%, which was similar to that of 27.2% in healthy controls. There were significant differences in the mean serum 25(OH) D level and prevalence of vitamin D deficiency between the two groups, with p-values of 0.049 and 0.009, respectively. The bone turnover markers of PINP and β-CTX in BPPV patients were lower than those in healthy controls. Logistic regression showed that vitamin D deficiency were associated with BPPV with an odds ratio of 3.8 (95% confidence interval = 1.25–11.73).Conclusion: Our study found that decreased serum vitamin D may be a risk factor for BPPV in male patients. The level of bone turnover among male patients with BPPV was lower than that among healthy controls.

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Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Cited by 52 publications

References 37 publications

Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Benign paroxysmal positional vertigo in the elderly: current insights

Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo

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