Bone Mineral Density Assessment by Quantitative Computed Tomography in Glucocorticoid-Treated Boys With Duchenne Muscular Dystrophy: A Linear Mixed-Effects Modeling Approach

Liu, Chuan; Yang, Dandan; Zhang, Lu; Lei, Xian-Gao; Jia, Feng-Lin; Liu, Yi; Chen, Xijian; Ning, Gang; Wen, Li; Qu, Haibo

doi:10.3389/fendo.2022.860413

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Unlike DXA, QCT distinguishes between morphological bone types, allowing for separate density measurement of the metabolically active trabecular bone, which is more susceptible to osteoporotic fractures and has a quicker response to treatment than cortical bone [36,37]. Recent studies in patients with similar risk factors to solid organ transplant patients, including children with Duchenne muscular dystrophy and neurofibromatosis type 1, suggest that serial QCT measurements may be more useful than DXA scans where BMD changes are influenced by variations in bone related to growth, scoliosis, body size, or body composition [38 ▪ ,39 ▪ ,40]. Pediatric reference data is available [41,42], however, variations in scanning and analysis protocols exist [43].…”

Section: Evaluation and Management Of Metabolic Bone Disease Followin...mentioning

confidence: 99%

Bone health in children undergoing solid organ transplantation

Pinto,

Muzumdar,

Hecht Baldauff

2023

Current Opinion in Pediatrics

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Purpose of review Pediatric solid organ transplant recipients are a unique and growing patient population who are at risk for metabolic bone disease both before and after transplantation. Recent findings The odds of sustaining a fracture in adulthood are significantly higher if an individual has sustained at least one childhood fracture, therefore, close monitoring before and after transplant is essential. Emerging data in patients with chronic kidney disease mineral and bone disorder (CKD-MBD) and hepatic osteodystrophy highlights the role of fibroblast growth factor 23 in the pathogenesis of metabolic bone disease in these conditions. While dual X-ray absorptiometry (DXA) is the most widely used imaging modality for assessment of bone mass in children, quantitative computer tomography (QCT) is an emerging modality, especially for patients with glucocorticoid-induced osteoporosis. Summary Solid organ transplantation improves organ function and quality of life; however, bone mineral density can decline following transplantation, particularly during the first three to six months. Immunosuppressive medications, including glucocorticoids, are a major contributing factor. Following transplant, treatment should be tailored to achieve mineral homeostasis, correct nutritional deficiencies, and improve physical conditioning. In summary, early identification and treatment of metabolic bone disease can improve the bone health status of pediatric transplant recipients as they enter adulthood. Video abstract http://links.lww.com/MOP/A71

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Section: Evaluation and Management Of Metabolic Bone Disease Followin...mentioning

confidence: 99%

Bone health in children undergoing solid organ transplantation

Pinto,

Muzumdar,

Hecht Baldauff

2023

Current Opinion in Pediatrics

View full text Add to dashboard Cite

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Different bone health progression patterns and early-stage risk marker in glucocorticoid-treated ambulatory Duchenne muscular dystrophy

Zhou,

et al. 2024

Osteoporos Int

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Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K‐AKT and apoptosis pathways

Xu,

Zhang,

Zhou

et al. 2024

J Cellular Molecular Medi

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Osteoporosis (OP), a systemic skeletal disease, is characterized by low bone mass, bone tissue degradation and bone microarchitecture disturbance. Bazi Bushen, a Chinese patented medicine, has been demonstrated to be effective in attenuating OP, but the pharmacological mechanism remains predominantly unclear. In this study, the senescence‐accelerated mouse prone 6 (SAMP6) model was used to explore bone homeostasis and treated intragastrically for 9 weeks with Bazi Bushen. In vivo experiments showed that Bazi Bushen treatment not only upregulated the levels of bone mineral density and bone mineral content but also increased the content of RUNX2 and OSX. Furthermore, the primary culture of bone mesenchymal stem cells (BMSCs) in SAMP6 mice was used to verify the effects of Bazi Bushen on the balance of differentiation between osteoblasts and adipocytes, as well as ROS and aging levels. Finally, the pharmacological mechanism of Bazi Bushen in attenuating OP was investigated through network pharmacology and experimental verification, and we found that Bazi Bushen could significantly orchestrate bone homeostasis and attenuate the progression of OP by stimulating PI3K‐Akt and inhibiting apoptosis. In summary, our work sheds light on the first evidence that Bazi Bushen attenuates OP by regulating PI3K‐AKT and apoptosis pathways to orchestrate bone homeostasis.

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Bone Mineral Density Assessment by Quantitative Computed Tomography in Glucocorticoid-Treated Boys With Duchenne Muscular Dystrophy: A Linear Mixed-Effects Modeling Approach

Cited by 4 publications

References 45 publications

Bone health in children undergoing solid organ transplantation

Bone health in children undergoing solid organ transplantation

Different bone health progression patterns and early-stage risk marker in glucocorticoid-treated ambulatory Duchenne muscular dystrophy

Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K‐AKT and apoptosis pathways

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