Bone mineral density in a population with severe infantile cerebral palsy

Díaz, Antonio; Farrington, D.M.; Carmona, Francesc; Moreno, Mónica Cárdenas; Olmo, J.J. Quintana del

doi:10.1016/j.recote.2012.06.006

Cited by 4 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone attenuation of the acetabulum and femoral neck decreased as GMFCS level increased. Previous studies have reported a similar relationship . For example, Henderson et al and Tatay Diaz et al found that BMD was lower in patients in GMFCS level V than in those in level IV.…”

Section: Discussionmentioning

confidence: 58%

Osteopenic features of the hip joint in patients with cerebral palsy: a hospital‐based study

Moon¹,

Kwon

Cho

et al. 2016

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 58%

Osteopenic features of the hip joint in patients with cerebral palsy: a hospital‐based study

Moon¹,

Kwon

Cho

et al. 2016

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

Use of iliac crest allograft for Dega pelvic osteotomy in patients with cerebral palsy

Sung

Kwon

Chung

et al. 2018

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundDega pelvic osteotomy is commonly performed procedure in patients with cerebral palsy (CP) undergoing hip reconstructive surgery for hip displacement. However, there has been no study investigating the outcomes after Dega pelvic osteotomy using allograft in patients with CP. This study investigated the outcomes of Dega pelvic osteotomy using iliac crest allograft in CP with hip displacement and the factors affecting allograft incorporation.MethodsThis study included 110 patients (150 hips; mean age 8y7mo; 68 males, 42 females) who underwent hip reconstructive surgeries including Dega pelvic osteotomy using iliac crest allograft. To evaluate the time of allograft incorporation, Goldberg score was evaluated according to the follow-up period on all postoperative hip radiographs. The acetabular index, migration percentage, and neck-shaft angle were also measured on the preoperative and postoperative follow-up radiographs.ResultsThe mean estimated time for allograft incorporation (Goldberg score ≥ 6) was 1.1 years postoperatively. All hips showed radiographic union at the final follow-up and there was no case of graft-related complications. Patients with Gross Motor Function Classification System (GMFCS) level V had 6.9 times higher risk of radiographic delayed union than those with GMFCS level III and IV. Acetabular index did not increase during the follow-up period (p = 0.316).ConclusionsDega pelvic osteotomy using iliac crest allograft was effective in correcting acetabular dysplasia, without graft-related complications in patients with CP. Furthermore, the correction of acetabular dysplasia remained stable during the follow-up period.

show abstract

Changes in bone metabolism during cerebral palsy

Maslova

Звонкова

Боровик

et al. 2022

RPJ

View full text Add to dashboard Cite

Introduction. Patients with cerebral palsy (CP) are especially vulnerable to the development of osteopenia. Skeletal deformities caused by immobility (prolonged bed rest, limited exercise, immobilization), antiepileptic drugs, hormonal and genetic factors can lead to significant bone loss. Diagnosis of osteoporosis includes densitometry and the study of biochemical markers to assess the state of bone mineralization at the time of the examination. However, densitometry in patients with cerebral palsy may present certain difficulties. Purpose is to determine changes in the content of bone tissue metabolism markers in CP patients depending on the severity of movement disorders. Materials and methods. We examined 32 CP patients aged 2 to 15 years for 3 months who were in rehabilitation in 2019-2021. The patients were divided into 2 groups: 18 children in the main group with motor dysfunctions of level IV-V and 14 children in the comparisons group - with disorders of I-III levels. All children underwent an analysis of anthropometric parameters using the program “WHO AnthroPlus (2009)”, determination of the blood levels of biochemical markers of bone tissue metabolism: calcium, phosphorus, alkaline phosphatase, osteocalcin, vitamin D, parathyroid hormone, bone resorption marker β-CrossLaps. Results. The indices of alkaline phosphatase, calcium and phosphorus in the majority of CP patients (88%) were within the reference values. The average concentrations of these compounds did not differ significantly in CP patients in the main group and the comparison group, including between children who received and did not receive antiepileptic drugs. There were no significant differences in 25(OH)D concentrations in patients of these groups. CP patients from the main group were found to be supplemented with vitamin D less frequently than children from the comparison group. Indicators of bone tissue resorption (β-CrossLaps) in patients with cerebral palsy increased significantly more than in patients of the comparison group, which indicates a pronounced loss of bone mass in severe impairment of motor functions. More than half of CP patients have high values of the bone resorption marker β-CrossLaps, which, together with an increase in the level of osteocalcin, indicates active osteoreparation, which is higher in children with severe motor disorders. At the same time, a close correlation (r = 0.596; p < 0.05) between the levels of osteocalcin and β-CrossLaps in patients may indicate activation of bone tissue repair in response to pronounced resorption. However, it should be noted that the determination of biomarkers of bone tissue metabolism in children with cerebral palsy is not indicative in the detection of osteopenia and osteoporosis due to the characteristics of these patients: reduced motor activity, growth retardation and psychophysical development.

show abstract

Bone mineral density in a population with severe infantile cerebral palsy

Cited by 4 publications

References 24 publications

Osteopenic features of the hip joint in patients with cerebral palsy: a hospital‐based study

Osteopenic features of the hip joint in patients with cerebral palsy: a hospital‐based study

Use of iliac crest allograft for Dega pelvic osteotomy in patients with cerebral palsy

Changes in bone metabolism during cerebral palsy

Contact Info

Product

Resources

About