Bone Mineral Density in Adolescents With Eating Disorders Exposed to Selective Serotonin Reuptake Inhibitors

Abstract

Retrospective chart review was used to collect data from adolescents seen in a specialized eating disorder program over an 11-year period in order to investigate any association between exposure to selective serotonin reuptake inhibitors (SSRIs) and bone mineral density (BMD). SSRI users were matched with controls based on age (within 1.5 years), gender, eating disorder diagnosis, and percent ideal body weight (within 5%), resulting in a sample of 31 pairs. SSRI users had significantly lower BMD z-scores, compared to controls (-1.094 vs. -0.516, p < .035), suggesting that exposure to SSRIs may be a risk factor for lowered BMD.

Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa

“…Adult investigations 7–9 and studies of AN 10,11 have shown similar skeletal effects of antidepressants. We found that trabecular vBMD, cortical CSA, cortical thickness, section modulus, and maximal muscle CSA by pQCT were negatively correlated with antidepressant use.…”

The use of antidepressants is linked to bone loss: A systematic review and metanalysis

“…Then, 14 manuscripts of the remaining 32 papers were excluded because they did not fulfill the criteria for inclusion, while the remaining 18 were included in the qualitative analysis and 5 in the quantitative analysis (Figure 1). 14,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]…”

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

“…Além do quadro de AN e baixo peso em si, o uso abusivo de álcool, tabagismo (MUNN-CHERNOFF et al, 2021), excesso de vitamina A (MIRA et al, 1989), baixa ingestão de cálcio, insuficiência de vitamina D (HOTTA, 2018), amenorreia , depressão e uso de medicamentos, como ISRS (COUTURIER et al, 2013), acentuam ainda mais o risco para osteoporose em indivíduos com TA.…”