Bone-mineral density in children and adolescents who have spastic cerebral palsy.

Henderson, Richard C.; Lin, Patrick P.; Greene, Walter B.

doi:10.2106/00004623-199511000-00005

Cited by 214 publications

(179 citation statements)

References 42 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…1 ± 5 The causes of this osteopenia are likely to be multiple and include: immobilization, poor nutrition, low calcium intake and anticonvulsant medication. 2 Osteopenia has been assessed by means of dual energy X-ray absorptiometry (DEXA) by several authors. 1,2,5 The bone mineral density (BMD) of children and adolescents with spastic cerebral palsy was generally below that of their age-matched normal controls.…”

Section: Introductionmentioning

confidence: 99%

“…2 Osteopenia has been assessed by means of dual energy X-ray absorptiometry (DEXA) by several authors. 1,2,5 The bone mineral density (BMD) of children and adolescents with spastic cerebral palsy was generally below that of their age-matched normal controls. Ambulatory status was the factor that best correlated with BMD, followed by nutritional status.…”

Section: Introductionmentioning

confidence: 99%

“…Ambulatory status was the factor that best correlated with BMD, followed by nutritional status. 2 Some authors related this osteopenia to the high prevalence of low vitamin D levels in severely handicapped children and adolescents 4 although others failed to demonstrate any correlation between serum vitamin D levels and BMD 2 or between nutrition and growth parameters. 3 Moreover, serum levels of calcium, phosphate, alkaline phosphatase and osteocalcin were not reliable indicators of low BMD.…”

Section: Introductionmentioning

confidence: 99%

“…3 Moreover, serum levels of calcium, phosphate, alkaline phosphatase and osteocalcin were not reliable indicators of low BMD. 2 Although the physiopathological mechanism behind osteopenia is not really the same, paralytic patients with spinal cord injuries (SCI) also show a loss of bone in areas located below the lesion caused by an early increase of bone remodeling. 6 ± 8 This osteoporo-sis is also characterized by lower bone mineral content (BMC), bone mineral density (BMD), decreased trabecular bone volume (TBV) 9 and an increased osteoclastic resorption surface.…”

Section: Introductionmentioning

confidence: 99%

“…To determine if the reduced bone formation generally observed in immobile patients 2,5 was associated with de®cient OB or BM capacities, we compared their in vitro viability, proliferation and di erentiation parameters with those of cells coming from normal controls. Also, for the ®rst time, a distinction has been made between spastic and¯accid patients during study of the in vitro characteristics of osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparative study of the in vitro characteristics of osteoblasts from paralytic and non-paralytic children

et al. 2000

View full text Add to dashboard Cite

Study design: Cerebral palsy is known to provoke a high loss of bone in children and adults. The potential interest of human osteoblastic cell culture for assessing the osteoblastic function in metabolic bone disorders has been demonstrated by many previous studies. Few studies have attempted to evaluate the capacities of osteoblasts isolated from immobilized or normal bones by in vitro culture methods. Moreover, a few teams did make the distinction between young spastic and¯accid patients. Objectives: We attempted to characterize mature osteoblasts (OB) and bone marrow-stromal cells (BM) originating from 56 immobile and normal children. Spastic and¯accid patients formed the paralytic group. Setting: France. Methods: Osteoblasts and bone marrow cells were isolated from iliac crests obtained during pelvic osteotomies of young control and paralytic patients. The in vitro viability, proliferation and di erentiation parameters of the cells from paralytic patients were compared with those of cells coming from normal controls. Results: No signi®cant di erences in the cell proliferation parameters were observed between the two groups. Only initial cell viability before inoculation was lower for the paralytic group, compared to the control group. On the other hand, contrary to expectations, we found that fresh and thawed OB cells from¯accid patients synthesized more osteocalcin and more collagen respectively than those of the spastic and control groups. Opposite results were obtained from BM cultures. Conclusion: A negative feedback mechanism by systemic or local factors, which is not conserved in vitro but controls the in vivo osteocalcin and collagen synthesis of¯accid paralytic OB cells, is hypothesized. Because these¯accid patients are known to have a high fat/lean mass, we suggest that leptin may be the potential regulating factor implicated in the hypothesized negative feedback mechanism. Spinal Cord (2000) 38, 622 ± 629

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparative study of the in vitro characteristics of osteoblasts from paralytic and non-paralytic children

et al. 2000

View full text Add to dashboard Cite

show abstract

Growth and nutrition disorders in children with cerebral palsy

Kuperminc

Stevenson

2008

Dev Disabil Res Revs

198

138

View full text Add to dashboard Cite

Growth and nutrition disorders are common secondary health conditions in children with cerebral palsy (CP). Poor growth and malnutrition in CP merit study because of their impact on health, including psychological and physiological function, healthcare utilization, societal participation, motor function, and survival. Understanding the etiology of poor growth has led to a variety of interventions to improve growth. One of the major causes of poor growth, malnutrition, is the beststudied contributor to poor growth; scientific evidence regarding malnutrition has contributed to improvements in clinical management and, in turn, survival over the last 20 years. Increased recognition and understanding of neurological, endocrinological, and environmental factors have begun to shape care for children with CP, as well. The investigation of these factors relies on advances made in the assessment methods available to address the challenges inherent in measuring growth in children with CP. Descriptive growth charts and norms of body composition provide information that may help clinicians to interpret growth and intervene to improve growth and nutrition in children with CP. Linking growth to measures of health will be necessary to develop growth standards for children with CP in order to optimize health and well-being.

show abstract

Osteoporosis Epidemiology Among Adults With Cerebral Palsy: Findings From Private and Public Administrative Claims Data

2019

View full text Add to dashboard Cite

Individuals with cerebral palsy (CP) have an increased risk for the early development of osteoporosis; however, little is known about the epidemiology of osteoporosis for adults with CP, which is vital to inform clinical practice for osteoporosis prevention, treatment, and management. The purpose of this cross‐sectional study was to determine sex‐stratified prevalence of osteoporosis among adults with CP, as compared with adults without CP. Data from 2016 were extracted from Optum Clinformatics Data Mart (private insurance administrative claims data) and a random 20% sample from the fee‐for‐service Medicare (public insurance administrative claims data). Diagnostic codes were used to identify CP and osteoporosis diagnoses. Sex‐stratified prevalence of osteoporosis was compared between adults with and without CP for the following age groups: 18 to 30, 31 to 40, 41 to 50, 51 to 60, 61 to 70, and >70 years of age. The overall prevalence of osteoporosis was 4.8% for adults without CP (n = 8.7 million), 8.4% for privately insured adults with CP (n = 7,348), and 14.3% for publicly insured adults with CP (n = 21,907). Women and men with CP had a higher prevalence of osteoporosis compared with women and men without CP for all age groups. Finally, publicly insured women and men with CP had a higher prevalence of osteoporosis compared with privately insured women and men with CP for all age groups, except for the similar prevalence among the 18‐ to 30‐year age group. These findings suggest that osteoporosis is more prevalent among adults with CP compared with adults without CP. Study findings highlight the need for earlier screening and preventive medical services for osteoporosis management among adults with CP. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research

show abstract

Bone-mineral density in children and adolescents who have spastic cerebral palsy.

Cited by 214 publications

References 42 publications

Comparative study of the in vitro characteristics of osteoblasts from paralytic and non-paralytic children

Comparative study of the in vitro characteristics of osteoblasts from paralytic and non-paralytic children

Growth and nutrition disorders in children with cerebral palsy

Osteoporosis Epidemiology Among Adults With Cerebral Palsy: Findings From Private and Public Administrative Claims Data

Contact Info

Product

Resources

About