Bone mineral density in postmenopausal Mexican-Mestizo women with normal body mass index, overweight, or obesity

Méndez, Juan Pablo; Rojano-Mejía, David; Galindo, Javier Leonardo; Coral‐Vázquez, Ramón Mauricio; Soriano, Ruth; García-García, Eduardo; Aguirre-García, María del Carmen; Coronel, Agustín; Canto, Patricia

doi:10.1097/gme.0b013e318277694f

Cited by 34 publications

(26 citation statements)

References 25 publications

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“…In our cohort, the only factor that we found associated with low BMD was the presence of low height and weight, which is in agreement with data that other authors found in general population and other Sle patients' series [17]. Reduced BMD and lean body mass are prevalent in patients with Sle [18].…”

Section: Discussionsupporting

confidence: 94%

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region

et al. 2014

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Studies have found an increase in bone loss and fracture in individuals with systemic lupus erythematosus (SLE) compared with general population. The aim of this study was to describe the prevalence of osteopenia, osteoporosis, and fragility fractures and to find potential predictors of bone loss in our cohort of SLE patients. We performed a cross-sectional study and collected 67 bone density measurements (BMD) of our SLE patients. We also collected sociodemographic data, 25-OH-vitamin D levels, serological markers, activity index, SLE cumulative damage index, and pharmacologic treatment. Sixty-seven consecutive BMD from SLE patients were assessed. Osteopenia was found in 28-46% of SLE patients. Osteoporosis ranged from 3 to 6%[corrected]. The only statistically significant correlation we found was between weight and height with total hip and femoral neck BMD (p < 0.05). The most frequent BMD-affected site was at the femoral neck, showing osteopenia in 40.3% [corrected] of SLE patients. Osteoporosis was found in up to 6% [corrected] of SLE patients. We found no predictors of bone loss in relation to the disease activity or its treatment. Fragility fractures were seen in 4.4% of SLE patients. All patients with fragility fractures showed osteopenia at BMD. There is a high prevalence of bone loss in SLE patients, since up to 40% [corrected] of SLE patients showed low BMD. Total hip and femoral neck osteopenia were the most frequent findings correlated with low BMI. We found a lower prevalence of fragility fractures compared with other series.

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Section: Discussionsupporting

confidence: 94%

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region

et al. 2014

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“…Therefore, it should be emphasized that serum or plasma OPN levels measured even with the same detection system could only be used for reference to each other. Age and BMI, known as the significant predictors for postmenopausal osteoporosis [11,12], did have correlation with OPN levels in our study subjects. This study was in line with precious studies by Chang [11] and Fodor [12], but another study found no association between serum OPN levels and age or BMI [9].…”

Section: Discussionmentioning

confidence: 54%

“…Age and BMI, known as the significant predictors for postmenopausal osteoporosis [11,12], did have correlation with OPN levels in our study subjects. This study was in line with precious studies by Chang [11] and Fodor [12], but another study found no association between serum OPN levels and age or BMI [9]. However, an interesting observation was that the only negative correlation between serum OPN levels and BMI was found in the osteoporotic subgroup.…”

Section: Discussionmentioning

confidence: 54%

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Wei

Huang

Tan

et al. 2015

Scandinavian Journal of Clinical and Laboratory Investigation

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Osteopontin (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblast and osteocytes and associated with bone turnover and bone mineral density (BMD) in postmenopausal women. Here, we aimed to investigate the relationship between circulating OPN levels and BMD in postmenopausal women in Southern China. A total of 362 postmenopausal women were consecutively recruited into this study from 2011-2013. Serum levels of OPN, receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL), and bone turnover markers were analyzed. BMD was measured by dual energy X-ray absorptiometry. Osteoporosis and osteopenia were diagnosed according to the World Health Organization criteria. Serum OPN levels were remarkably higher in the osteoporotic group than those in the osteopenic and normal groups (all p < 0.001). The cut-off value of OPN for diagnosing postmenopausal osteoporosis was 10.1 ng/mL, which had a sensitivity of 89.5%, a specificity of 70.8%, and an area under curve of 0.953. Serum OPN was negatively correlated with parathyroid hormone (PTH), lumbar spine BMD, and femoral neck BMD (r = -0.25, p = 0.004; r = -0.66, p < 0.001; r = -0.28, p = 0.001; respectively) and positively associated with type I procollagen amino-terminal propeptide (PINP), carboxy-terminal cross-linking telopeptide of type I collagen (CTX), and RANKL (r = 0.20, p = 0.020; r = 0.17, p = 0.036; r = 0.19, p = 0.028, respectively) in the osteoporotic group. In multiple regression analyses, lumbar spine BMD, PTH and RANKL were the predictors for serum OPN levels. In conclusion, OPN serum levels are negatively related to BMD and positively correlated with bone turnover levels in this group of Chinese postmenopausal women.

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“…Previous studies have reported higher BMD in overweight and obese women compared with normal weight women (2,12,18,19). While many of these reports have examined the relationship between BMI and changes in BMD by BMI categories, it is noteworthy that this study observed a strong continuous relationship between BMI and BMD levels in a sample of women where 73.3% of women were obese and 22.5% were overweight.…”

Section: Discussionmentioning

confidence: 81%

Bone mineral density in midlife women: the Study of Women's Health in Qatar

et al. 2014

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Objectives The aim of this study is to investigate bone mineral density (BMD) for a large cross-section of midlife Arab women living in Qatar and to evaluate the association of body mass index, menopause status, and nationality, on BMD of the spine and femur. Study design A cross-sectional study was conducted among women aged 40–60 recruited from nine primary care health centers in Qatar. BMD (g/m2) was assessed at the lumbar spine and the femur. Results The combined prevalence of osteopenia and osteoporosis was 4% at the femur and 16.2% at the spine. BMI and menstrual status were both independently associated with BMD at the spine and at the femur (all p values <0.001). As BMI increased, BMD increased at both the spine and femur. Women who menstruated in the past 12 months had 0.82 g/cm2 and 0.61 g/cm2 greater BMD at the spine and femur, respectively, compared with women who had not menstruated in 12 months. Nationality was not associated with mean BMD of the spine or the femur. Conclusions No significant differences were observed between Qatari and non-Qatari women in terms of mean BMD values at the spine and the femur except for femur in the age group 55–60, where values were lower among non-Qataris (p=0.04). Multivariate analysis showed that BMI and menstrual status were found to be strongly associated with BMD levels at the spine and femur. The high prevalence of obesity observed in this sample may explain the low levels of osteopenia and osteoporosis observed.

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Bone mineral density in postmenopausal Mexican-Mestizo women with normal body mass index, overweight, or obesity

Abstract: A higher BMI is associated significantly and positively with a higher BMD at the LS, TH, and FN.

Cited by 34 publications

References 25 publications

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Bone mineral density in midlife women: the Study of Women's Health in Qatar

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