Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey

Aslan, İbrahim; Canatan, Duran; Baltă, N; Kaçar, Gülizar; Dorak, Cengaver; Özsancak, A; Oğuz, Nurgül; Coşan, Rüya

doi:10.1155/2012/573298

Cited by 23 publications

(20 citation statements)

References 10 publications

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“…Calcium-phosphorus balance, which may be due to the use of iron chelators, is one of the factors that contribute to development of osteoporosis in thalassemic patients [29]. Therefore, as our patients are exhibiting significantly reduced levels of calcium and phosphorus together with the reported correlation between calcium and hepatocellular injury, regular nutritional assessments should be done with specific attention, but not limited, to iron-containing foods, calcium, and phosphorus.…”

Section: Discussionmentioning

confidence: 94%

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

Sirdah¹

2013

J Genet Disor Genet

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Section: Discussionmentioning

confidence: 94%

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

Sirdah¹

2013

J Genet Disor Genet

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“…Mahachoklertwattana et al [6] found iPTH levels were higher than in healthy controls. Aslan et al found high serum PTH levels in TM patients but reported no relationship between PTH and BMD [33]. Diabetes is the most common endocrine complication in thalassemia.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Bone Mineral Density in Patients with Thalassemia Major

Özkan¹

2016

Eu Clin Anal Med

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ÖzetAmaç: Bu çalışmayla talasemi majorlu (TM) hastalarda kemik mineral dansitometri (KMD) ve biyokimyasal parametreler kullanarak osteopatinin değer-lendirilmesi ve osteoporozun erken teşhisi ve alınacak önlemlerin vurgulanması amaçlanmıştır. Gereç ve Yöntem: 37 TM 'li hasta (18 kız, 19 erkek) ça-lışmaya alınmıştır. Yaş cinsiyet ve biyokimyasal veriler kaydedildi. BMD dual enerji X-ray absorbtiometri kullanılarak lumbar vertebradan ölçüldü. Z skoru makina tarafından otomatik olarak hesaplandı. Z skoruna göre <-1 normal, -1-2 osteopeni, > -2 osteoporoz olarak değerlendirildi. Bulgular: 9 hastanın (%24.3) Z skoru normal, 5 hasta (%13.5) osteopenik, 23 hasta (%62.2) osteoporotik idi. Osteoporotik grupta 2 hastada (%5.4) paratiroid hormon (PTH) düzeyleri düşük ve vitamin D düzeyleri 12 hastada (%32.4) yetersizdi.Lumbar KMD yaş (r=0.625, P=0.000), boy (r = 0.759, P =0.000), kilo (r=0.830, P=0.000), vücut kitle indeksi (VKI) ile pozitif korele (r=0.730, P=0.000) and alkalen fosfataz (ALP) (r=-0.422, P=0.010) ile negatif korele idi. Tartışma: Dü-zenli transfüzyona rağmen osteopati TM li hastalarda yüksek oranda görü-lebilir. Anahtar KelimelerKemik Mineral Dansitometri; Osteoporoz; Talasemi Major Abstract Aim: We aim to evaluate osteopathy in patients with thalassemia major (TM) by performing bone mineral densitometry (BMD) and biochemical indices and to emphasize preventive measures and the importance of early diagnosis of osteoporosis. Material and Method: 37 TM patients (18 female, 19 male) were included in the study. The age, gender, biochemical parameters were recorded. BMD was determined using dual energy X-ray absorptiometry from lumbar vertebrae. Z scores were calculated automatically by the device. According to Z scores; <-1 was normal, -1-2 was osteopenia, >-2 was considered as osteoporosis. Results: 9 patients' Z scores (24.3%) were normal, 5 patients were osteopenic (13.5%), and 23 patients were osteoporotic (62.2%). In the osteoporotic group, parathyroid hormone (PTH) was low in 2 patients (5.4%) and vitamin D was deficient in 12 (32.4%) patients. Lumbar BMD was positively correlated with age (r=0.625, P=0.000), height (r = 0.759, P =0.000), weight (r=0.830, P=0.000), and BMI (r=0.730, P=0.000), and was negatively correlated with ALP (r=-0.422, P=0.010). In the osteopenic group, vitamin D was deficient in 2 patients (5.4%); all other biochemical parameters were within normal limits. Lumbar BMD was positively correlated with age (r=0.625, P=0.000), height (r=0.759, P=0.000), weight (r=0.830, P=0.000), and body mass index (BMI) (r=0.730, P= 0.000), and was negatively correlated with alkaline phosphatase (ALP) (r= -0.422, P= 0.010). Discussion: Despite regular transfusions, osteopathy may occur at high rates in patients with thalassemia. Keywords IntroductionBeta thalassemias are a group of autosomal inherited disorders characterized by globin chain mutations in the hemoglobin tetramer and are due to defective hemoglobin synthesis; severe anemia, bone marrow expansion, skeletal deformity, and increased gastro...

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“…The high prevalence of osteoporosis because of delayed puberty was published in our center. 10 Regular voluntary blood donations and transfusions are the most important issue in patients with TM. The donation rate varies across countries depending on the population.…”

Section: Discussionmentioning

confidence: 99%

The Thalassemia Center of Antalya State Hospital

Canatan¹

2013

Journal of Pediatric Hematology/Oncology

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The Thalassemia center of Antalya State Hospital was established in 1994 in Antalya, Turkey. The number of newborns with thalassemia decreased statistically because of actions taken as a result of prevention studies. A total of 388 patients, including 246 with thalassemia major (63.4%), 86 with thalassemia intermediate (22.1%), 23 with sickle cell+β-thalassemia (5.9%), 20 with sickle cell disease (5.1%), and 13 with other hemoglobin abnormalities (3.3%), were studied. Complications were found to be as follows: cardiomyopathy in 45 of them (11.5%), diabetes mellitus in 10 (2.5%), hypothyroidism in 17 (4.3%), hypoparathyroidism in 2 (0.5%), osteoporosis in 53 (13.6%), growth retardation in 110 (28.3%), and hypogonadism in 75 patients (19.3%). The incidence of autoantibody and alloantibody in patients with thalassemia major was 5.6% and 10.5%, respectively. Transfusion-transmission diseases evaluated in patients found the incidence of hepatit A virus IgG to be 97.5%, that of HBs Ab to be 99.5%, HBs Ag to be 0.5%, HCV Ab to be 18%, CMV IgG to be 72.3%, CMV IgM to be 2%, and HIV-Ab to be 0%. Therefore, for the first time in our country the thalassemia center was established as a model and included subunits and a team. It served all patients for 15 years until the team was dispersed; thereafter, most of the patients were not followed up on a regular basis.

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Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey

Cited by 23 publications

References 10 publications

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

The Evaluation of Bone Mineral Density in Patients with Thalassemia Major

The Thalassemia Center of Antalya State Hospital

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