Bone mineral density in Turner's syndrome and the influence of pubertal development

Nadeem, Montasser; Roche, Edna

doi:10.1111/apa.12435

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Compared with healthy women, women with TS women had a low BMD at age 15-39 years. Similar results for BMD were confirmed in other countries as well [16,[22][23][24][25] .…”

Section: Discussionsupporting

confidence: 88%

A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan

et al. 2020

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Osteoporosis is one of the clinical features of women with Turner syndrome (TS). The reasons for low bone mineral density (BMD) and increased bone fragility are multifactorial, including estrogen deficiency, X-chromosome abnormalities, and environmental factors. Few, large-scale studies on bone mineral density in either adolescents or adults with TS have been done in Japan. The goal of the present study was to investigate spinal BMD in women with TS, assess its relationship with clinical parameters, especially estrogen replacement therapy, and investigate its longitudinal changes. The spinal BMD and clinical data of 149 Japanese women with TS aged 15 to 49 years who were followed at the four participating hospitals were retrospectively analyzed. The BMD Z-scores of the women with TS ranged from-5.30 to +1.89. Women with TS aged 15-39 years had lower BMD than healthy Japanese women (p < 0.01) while women with spontaneous menstruation had a significantly higher BMD Z-score than those without spontaneous menstruation (-0.73 ± 1.11 vs.-1.67 ± 1.18, p < 0.01). In women without spontaneous menstruation, BMD Z-scores correlated with the duration of their estrogen therapy (r = 0.167, p < 0.01). Women aged 15-39 years with TS had low BMD, which was associated with primary amenorrhea and short estrogen replacement therapy duration.

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“…Compared with healthy women, women with TS women had a low BMD at age 15-39 years. Similar results for BMD were confirmed in other countries as well [16,[22][23][24][25] .…”

Section: Discussionsupporting

confidence: 88%

A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan

et al. 2020

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“…21 Similar results have been obtained by other authors. 5,34,35 Furthermore, karyotype did not influence densitometric Z-score values, which was also in an agreement with previous studies. 34,36 Our study may have been limited by its cross-sectional design and the small number of subjects studied.…”

Section: Discussionsupporting

confidence: 92%

The assessment of skeletal status in young patients with Turner syndrome by 2 densitometric techniques: Phalangeal quantitative ultrasound and dual energy X-ray absorptiometry

Wikiera¹,

Mierzwicka²,

Basiak³

et al. 2018

Adv Clin Exp Med

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“…This is similar to previous clinical series (7,14,22,23) , which reported mosaicism in between 30% and 50%. However, other studies have reported a higher incidence of mosaicism in up to 90% (6,11,24) .…”

Section: Discussionsupporting

confidence: 92%

Mode of initial presentation and chromosomal abnormalities in Irish patients with Turner syndrome: a single-centre experience

Mohamed¹,

Roche

Hoey³

2015

Journal of Pediatric Endocrinology and Metabolism

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Bone mineral density in Turner's syndrome and the influence of pubertal development

Cited by 14 publications

References 36 publications

A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan

A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan

The assessment of skeletal status in young patients with Turner syndrome by 2 densitometric techniques: Phalangeal quantitative ultrasound and dual energy X-ray absorptiometry

Mode of initial presentation and chromosomal abnormalities in Irish patients with Turner syndrome: a single-centre experience

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