Bone mineral density in young Chilean patients with type 1 diabetes mellitus

Mosso, Constanza; Hodgson, María Isabel; Ortiz, T.; Reyes, María Loreto

doi:10.1515/jpem-2015-0097

Cited by 10 publications

(16 citation statements)

References 12 publications

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“…It is possible that persistent alterations of calcium concentration could affect the insulin secretory response. In our study, weight-bearing treadmill running increased STZ-induced calcium excretion in serum, which is consistent with other findings in diabetic patients (36). Reports are variable about the high phosphorus level in T1DM (37).…”

Section: Discussionsupporting

confidence: 93%

Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway

et al. 2018

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Myostatin (MSTN) is not only a key negative regulator of skeletal muscle secretion, however is also an endocrine factor that is transmitted to bone. To investigate the effect and possible mechanism of weight-bearing treadmill running on bone with poorly controlled Type 1 diabetes, rats were randomly divided into three groups: Normal control (NC), diabetic mellitus (DM) and diabetic exercise training groups (DM-WTR). The DM-WTR rats were trained with weight-bearing running. The results demonstrated that the levels of serum insulin, body weight, bone mass, muscle mass, grip strength, and serum calcium in the DM-WTR rats were significantly increased, whereas the levels of blood glucose, alkaline phosphatase, and tartrate-resistant acid phosphatase were markedly reduced in the DM-WTR rats compared with the DM rats. Weight-bearing running inhibited streptozocin (STZ)-induced MSTN mRNA and protein expression in the diabetic rats. The mRNA and protein expression levels of activin type IIB receptor and mothers against decapentaplegic homolog 2/3 and its phosphorylation in femur DM-WTR rats were reduced compared with DM rats. In addition, weight-bearing running enhanced the STZ-induced Wnt and β-catenin expression levels and reduced the STZ-induced glycogen synthase kinase (GSK)-3β expression in diabetic rats' femora. In conclusion, the results suggested that weight-bearing running could partially ameliorate STZ-induced femur atrophy via MSTN downregulation, and this may be associated with the inactivation of Activin A Receptor Type 2B/Smad2/3 signaling pathways and the activation of the Wnt/GSK3β/β-catenin signaling pathway. Further studies are needed to verify these conclusions.

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Section: Discussionsupporting

confidence: 93%

Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway

et al. 2018

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“…These findings were supported with a larger sample size (n = 315) in the case-control study, which showed that low PA levels were associated with poor BMD at TB and LS in diabetic subjects (p < .01; Joshi et al, 2013). Three cross-sectional studies addressed the association between PA and daily insulin requirements (Beraki et al, 2014;Miculis, De Campos, & da Silva Boguszweski, 2015;Mosso et al, 2016). Daily MVPA was the independent variable in the three studies.…”

Section: Results On Physiological Outcomes In the Observational Studiesmentioning

confidence: 65%

“…However, five studies reported that BMI and body fat composition were not associated with habitual PA levels (Beraki et al, 2014;Cuenca-García et al, 2012;Mosso, Halabi, Ortiz, & Hodgson, 2015;Jegdic et al, 2013;Lukacs et al, 2012). The association between PA and bone health markers was investigated in two observational studies: one case-control (Joshi et al, 2013) and one cross-sectional (Mosso, Hodgson, Ortiz, & Reyes 2016). In the cross-sectional study, researchers examined the effect of habitual PA on BMD in 30 adolescents with T1D.…”

Section: Results On Physiological Outcomes In the Observational Studiesmentioning

confidence: 99%

A Systematic Review of Physical Activity and Exercise on Physiological and Biochemical Outcomes in Children and Adolescents With Type 1 Diabetes

Aljawarneh

Wardell

Wood

et al. 2019

J of Nursing Scholarship

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Purpose In this systematic review we aimed to evaluate the effects of physical activity (PA) and exercise on biochemical and physiological outcomes in children and adolescents with type 1 diabetes (T1D). Design The review was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Methods The search of literature was performed using PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, the Cochrane Library, Scopus, Medline, PsycINFO, the Nursing Reference Center, and Google Scholar. The search was limited to include peer‐reviewed articles published in English from May 2012 to May 2018 and included adolescents <19 years of age with T1D. Twenty‐seven studies met the inclusion criteria: 8 interventional and 19 observational studies. Findings Both observational and interventional studies showed considerable agreement that supervised regular moderate to vigorous physical activity (MVPA) is more effective on adiposity and cardiorespiratory fitness than habitual PA. Further, it was reported that PA of different intensities improves insulin sensitivity and decreases daily insulin dosage. Results of glycemic control were equivocal. Although observational studies reported improvement in glycemic control with PA of different intensities, most of the experimental studies revealed no significant associations. A consistent agreement among the studies revealed a considerable benefit of regular habitual PA of light to moderate intensity on blood glucose regulation and lipid profile. Conclusions The reviewed studies showed that regular MVPA was associated with several health benefits in adolescents with T1D; however, additional studies are needed to fully understand the effect of PA on health outcomes. Clinical Relevance Regular MVPA (at least 4 hr per week) with good glycemic control is a promising option for adolescents with T1D when risk management of hypoglycemia is appropriately taken.

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“…Onder et al [ 17 ] reported that 35% of 100 pediatric patients with T1DM showed abnormality of LS BMD ( z -scores < -1.0), similar to our study. In other studies about children and adolescents, the proportion of z-scores < -1 at LS ranged from 26.7% to 45.4% [ 9 , 10 , 18 , 19 ]. In prior studies, most children and adolescents with T1DM displayed significantly lower BMD at one or multiple skeletal sites, although a few studies detected no difference in BMD z -scores between T1DM patients and healthy controls [ 7 , 20 ].…”

Section: Discussionmentioning

confidence: 96%

Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes

Roh

Yoon

Park

et al. 2018

Ann Pediatr Endocrinol Metab

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PurposeMany studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD.MethodsPrepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI).ResultsThe mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8–11.3 years). Initial mean glycosylated hemoglobin (HbA1c) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA1c. Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023).ConclusionsPrepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.

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Bone mineral density in young Chilean patients with type 1 diabetes mellitus

Cited by 10 publications

References 12 publications

Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway

Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway

A Systematic Review of Physical Activity and Exercise on Physiological and Biochemical Outcomes in Children and Adolescents With Type 1 Diabetes

Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes

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