Bone Mineral Density of Human Female Cervical and Lumbar Spines From Quantitative Computed Tomography

Yoganandan, Narayan; Pintar, Frank A.; Stemper, Brian D.; Baisden, Jamie; Aktay, Recai; Shender, Barry S.; Paskoff, Glenn

doi:10.1097/01.brs.0000192684.12046.93

Cited by 63 publications

(66 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is generally accepted that the tBMD of the lumbar vertebra is lower than that of the thoracic vertebra, and the lumbar vertebra is more sensitive to age-related changes than the thoracic vertebra in humans. In addition, the study of Dominik et al reported that the tBMD of the lumbar vertebra is lower than that of the thoracic and cervical vertebrae [29]. Therefore, it is assumed that the lower tBMD of the lumbar vertebra compared with the thoracic vertebra in this study may reflect the difference in trabecular architecture between the thoracic and lumbar vertebrae in humans.…”

Section: Discussionmentioning

confidence: 52%

“…One study showed that mean tBMD values for women and men at the T12 vertebra (193.1/184.9 mg/cm 3 ) were higher than those at the L4 vertebra (186.2/180.1 mg/ cm 3 ) [28]. Another study revealed that the mean tBMD value at the T1 vertebra was higher than that at the L2 through L4 vertebrae in healthy female adults [29]. The present study showed significantly higher mean tBMD values for the entire thoracic vertebra than for the entire lumbar vertebra and a significantly higher mean tBMD value for the T13 vertebra than that of the L1 through L7 vertebrae in each group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

Cheon

Choi

Lee

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

. The aim of this study was to assess age-related changes and anatomic variation in trabecular bone mineral density (tBMD) using quantitative computed tomography (QCT) in normal cats. Seventeen normal cats were included in this study and divided into the following 3 age groups:<6 months (n=4), 2-5 years (n=10) and >6 years (n=3). A computed tomographic scan of each vertebra from the 12th thoracic to the 7th lumbar spine and the pelvis was performed with a bone-density phantom (50, 100 and 150 mg/cm 3 , calcium hydroxyapatite, CIRS phantom ® ). On the central transverse section, the elliptical region of interest (ROI) was drawn to measure the mean Hounsfield unit (HU) value. Those values were converted to equivalent tBMD (mg/cm 3 ) by use of the bone-density phantom and linear regression analysis (r 2 >0.95). The mean tBMD value of the thoracic vertebrae (369.4 ± 31.8 mg/cm 3 ) was significantly higher than that of the lumbar vertebrae (285 ± 58.1 mg/cm 3 ). The maximum tBMD occurred at the T12, T13 and L1 levels in all age groups. There was a statistically significant difference in the mean tBMD value among the 3 age groups at the T12 (P<0.001), T13 (P<0.001) and L4 levels (P=0.013), respectively. The present study suggests that age-related changes and anatomic variation in tBMD values should be considered when assessing tBMD using QCT in cats with bone disorders. KEY WORDS: bone mineral density, feline, quantitative computed tomography, trabecular bone. doi: 10.1292/jvms.11-0579; J. Vet. Med. Sci. 74(11): 1461-1467, 2012 Bone mineral density (BMD) decreases in accordance with normal aging and metabolic or systemic disease. The turnover rates for cancellous bone are 4 to 8 times greater than for cortical bone, so cancellous bone is more sensitive to disease-induced changes [25]. Therefore, in humans with osteoporosis, BMD has been primarily investigated in cancellous bone.On the basis of this relationship, several techniques have been developed to noninvasively measure bone mineralization at various skeletal sites. These include radioabsorptiometry (RA), single photon absorptiometry (SPA), dual photon absorptiometry (DPA), quantitative ultrasound (QUS), dual-energy x-ray absorptiometry (DEXA), quantitative computed tomography (QCT) and peripheral QCT (pQCT). Among these, DEXA, QCT and pQCT have become the established methods for evaluating skeletal status, assessing osteoporosis, determining fracture risk and monitoring metabolic diseases and therapies in humans [8,[10][11][12][13].Feline diseases affecting BMD include mucopolysaccharidosis, osteopetrosis, osteogenesis imperfect and osteopenia related to primary hyperparathyroidism and secondary to renal or nutritional hyperparathyroidism. Reports in cats have been limited to the studies for BMD evaluation using DEXA [17] and a few peer-reviewed studies that measured BMD in clinically normal cats and abnormal cats using DEXA [3,23]. DEXA has been accepted as the gold standard method of BMD measurement, and it requires less X-ray exposure for the patient...

show abstract

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

Cheon

Choi

Lee

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…The mean BMD (255 mg/cm 3 HA) of the third cervical vertebra in the normal group of the study was Yoganandan et al 11) reported that the correlation coefficients between the BMDs of the cervical and lumbar vertebrae ranged from 0.615 to 0.757 in young healthy adult male volunteers. The correlation coefficients in young healthy adult female volunteers ranged from 0.330 to 0.667, and the correlation coefficients of super-cervical vertebrae were lower than those of inferior cervical vertebrae 12) . Also, Weishaupt et al 19) reported that the correlation coefficient between the second cervical and fourth lumbar vertebrae in young healthy adult female volunteers was 0.379.…”

Section: Discussionmentioning

confidence: 99%

“…The number of teeth present and any periodontal parameters, including probing depth, probing attachment level, bleeding on probing and alveolar bone loss, did not differ among 3 groups in our previous study with the same patient group 13) . Yoganandan et al 12) reported that the mean BMD of the third cervical vertebra in young healthy adult female volunteers was 264.7 mg/ml. Also, Weishaupt et al 19) reported that the mean BMD of the second cervical vertebra in young healthy adult female volunteers was 297.2 mg/cm 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Also, the range of the correlation coefficients between the BMDs of cervical (C2-C7) and lumbar vertebrae (L2-L4) in young adult healthy female volunteers was from 0.330 to 0.667, and the correlation coefficients of C2 and C3 were lower than those of C6 and C7 12) . The purpose of this investigation was to clarify the relationship between the BMDs of cervical and lumbar vertebrae in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Bone Mineral Densities of Cervical and Lumbar Vertebrae in Postmenopausal Women

Naitoh

Tamaki

Kurosu

et al. 2014

J. Hard Tissue Biology.

View full text Add to dashboard Cite

For dental implant treatment, it is important to assess the general bone condition. Using multi-slice CT scans, we assessed the relationships between the bone mineral densities (BMDs) of the cervical and lumbar vertebrae in postmenopausal women to see if such data might be useful for imaging-based diagnosis prior to dental implant treatment. Thirty postmenopausal women were enrolled in this investigation, and their third cervical vertebrae were scanned for BMD using multi-slice computed tomography (CT) while the lumbar vertebrae were measured using dual energy X-ray absorptiometry, after which the percentage of the young adult mean (YAM) was calculated. The correlations between the BMD of the cervical vertebra and percentage of YAM were analyzed. The mean BMD of the cervical vertebra was 255 mg/cm 3 HA (s. : 35.9) in the osteoporosis group. A significant difference was observed between the normal and osteoporosis groups, and between the osteopenic and osteoporosis groups. A correlation (r = 0.705) was observed between the BMD of the cervical vertebrae and percentage of YAM of the lumbar vertebrae. The BMD of the third cervical vertebrae obtained from multi-slice CT images might be applicable in dental implant treatment to evaluate the influence of the general bone condition.

show abstract

Differences in vertebral bone density between African apes

Korpinen

2024

American Journal of Biological Anthropology

View full text Add to dashboard Cite

ObjectivesLow‐energy vertebral fractures are a common health concern, especially in elderly people. Interestingly, African apes do not seem to experience as many vertebral fractures and the low‐energy ones are even rarer. One potential explanation for this difference is the lower bone density in humans. Yet, only limited research has been done on the vertebral bone density of the great apes and these have mainly included only single vertebrae. Hence the study aim is to expand our understanding of the vertebral microstructure of African apes in multiple spinal segments.MaterialsBone density in the vertebral body of C7, T12, and L3 was measured from 32 Pan troglodytes and 26 Gorilla gorilla using peripheral quantitative computed tomography (pQCT).ResultsThere was a clear difference between the three individual vertebrae and consequently the spinal segments in terms of trabecular density and cortical density and thickness. The variation of these bone parameters between the vertebrae differed between the apes but was also different from those reported for humans. The chimpanzees were observed to have overall higher trabecular density, but gorillas had higher cortical density and thickness. Cortical thickness had a relatively strong association with the vertebral size.DiscussionDespite the similarity in locomotion and posture, the results show slight differences in the bone parameters and their variation between spinal segments in African apes. This variation also differs from humans and appears to indicate a complex influence of locomotion, posture, and body size on the different spinal segments.

show abstract

Bone Mineral Density of Human Female Cervical and Lumbar Spines From Quantitative Computed Tomography

Cited by 63 publications

References 14 publications

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

Relationship between Bone Mineral Densities of Cervical and Lumbar Vertebrae in Postmenopausal Women

Differences in vertebral bone density between African apes

Contact Info

Product

Resources

About