“…In vivo paracrine and autocrine signalling cascades leading to bone formation are complex and rely on strict spatiotemporal interplay between select growth factors. Teasing apart the individual roles that each growth factor plays within bone development and healing systems is of the highest (Aerssens et al, 1998;Kimmel and Jee, 1982;Neyt et al, 1998;Pearce et al, 2007;Skurla and James, 2005) (Aerssens et al, 1998;Mosekilde et al, 1993;Pearce et al, 2007;Thorwarth et al, 2005) Primates (Aerssens et al, 1998;Newman et al, 1995;Pearce et al, 2007;Ravaglioli et al, 1996) (Castaneda et al, 2006;Liebschner, 2004;Pearce et al, 2007) (Aerssens et al, 1998;Gomes and Fernandes, 2010;Liebschner, 2004;O'Loughlin et al, 2008) Table 4. Organic, inorganic and synthetic materials for orthopaedic applications in vivo.…”