2014
DOI: 10.1002/jcb.24856
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Bone Morphogenetic Protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction

Abstract: Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein-10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. After stimulation with the recombinant BMP10, an obvious dose-dependent cardiomyocyte proliferation and reentry of differentiated mammalian cardiomyo… Show more

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Cited by 31 publications
(32 citation statements)
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“…Importantly, Tbx20 OE induced 3 days after the onset of MI promotes adult CM proliferation in both the infarct border zone and remote area, improves survival, preserves cardiac function, and reduces infarct scar size, accompanied by improved cardiac hypertrophy and vascular density 4 weeks post-MI. Tbx20 OE in adult myocardium leads to activation of multiple signaling pathways, including PI3K/AKT 22, 23 , HIPPO/YAP 2426 and BMP/Smad1/5/8 27 , which have previously been shown to promote CM proliferation (Fig S12). Tbx20 also directly binds to and represses cell-cycle inibitory genes p21 and Meis1 , and a novel anti-proliferative protein gene Btg2, concomitant with inducing CM proliferation.…”
Section: Discussionmentioning
confidence: 94%
“…Importantly, Tbx20 OE induced 3 days after the onset of MI promotes adult CM proliferation in both the infarct border zone and remote area, improves survival, preserves cardiac function, and reduces infarct scar size, accompanied by improved cardiac hypertrophy and vascular density 4 weeks post-MI. Tbx20 OE in adult myocardium leads to activation of multiple signaling pathways, including PI3K/AKT 22, 23 , HIPPO/YAP 2426 and BMP/Smad1/5/8 27 , which have previously been shown to promote CM proliferation (Fig S12). Tbx20 also directly binds to and represses cell-cycle inibitory genes p21 and Meis1 , and a novel anti-proliferative protein gene Btg2, concomitant with inducing CM proliferation.…”
Section: Discussionmentioning
confidence: 94%
“…Cytokine interleukin 13 stimulated cell cycle reentry of neonatal rat ventricular cardiomyocytes and preferentially induced either proliferation or survival of CMs compared with other cell types 33 . TGF-beta superfamily growth factor BMP10 induced dose-dependent CM proliferation and cell cycle reentry of differentiated rat ventricular cardiomyocytes in vitro, and stimulated CM cell-cycle reentry and mitosis post-infarction in vivo by enhancing expression of the cardiac transcription factor Tbx20 34 . Similarly, paracrine factor C3orf58, a hypoxia and Akt induced stem cell factor, was shown to enhance cardiac repair in vivo and a 60% increase in DNA synthesis in neonatal rat ventricular myocytes 35 .…”
Section: Screening For Novel Regulators Of Cardiomyocyte Cell Cycle Amentioning
confidence: 97%
“…However, BMP10 has also been reported to reduce cardiac fibrosis and improve cardiac function following experimental myocardial infarction in mice. 111 …”
Section: H1 Bmps and The Cardiovascular Systemmentioning
confidence: 99%