2010
DOI: 10.1016/j.amjoto.2009.03.002
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Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma

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Cited by 14 publications
(14 citation statements)
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References 28 publications
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“…Furthermore, the in vitro effects on expression profiles of protein kinases and the in vivo effects on animal survival after transient exposure of OSCCA cell lines to rhBMP‐2 suggest that this pathway is functional and capable of being activated. Our data also confirmed the findings from other studies that the BMP‐2 expression levels of normal oral mucosal cells are absent to weak 10, 21…”
Section: Discussionsupporting
confidence: 92%
“…Furthermore, the in vitro effects on expression profiles of protein kinases and the in vivo effects on animal survival after transient exposure of OSCCA cell lines to rhBMP‐2 suggest that this pathway is functional and capable of being activated. Our data also confirmed the findings from other studies that the BMP‐2 expression levels of normal oral mucosal cells are absent to weak 10, 21…”
Section: Discussionsupporting
confidence: 92%
“…In contrast to the findings of the present study, Soares et al. (12) observed weak immunoexpression of BMPR‐IA in metastatic OSCC. This difference might be explained by the fact that these authors studied carcinomas involving different oral sites.…”
Section: Discussioncontrasting
confidence: 99%
“…In the present study, regarding the percentage of BMP-2-positive cells, a predominance of score 3 and strong staining were observed in the metastatic and nonmetastatic groups. Immunohistochemical studies have shown a high expression of BMP-2 ⁄ 4 (12,20) and BMP-5 (20) in OSCC, whereas low levels of these proteins were observed in normal differentiated tissues and benign neoplasms of the mouth. However, in the present study, despite the strong immunoexpression of BMP-2 in non-metastatic lesions, the expression of BMPR-IA and BMPR-II was found to be low in this group.…”
Section: Discussionmentioning
confidence: 99%
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“…Compared with normal mucosa, human oral squamous cell carcinoma (SCC) tumours overexpress BMP2 , BMP4, BMP5 and BMPR1A (ALK3), and metastatic lymph nodes retain strong BMP2, BMP4 and BMP5 expression [130,131]. A recent tissue microarray of HNSCC found that the majority of samples [132] (98%) expressed BMP2 .…”
Section: Role Of Bmp Signalling In Cancer Pathogenesismentioning
confidence: 99%