Bone morphogenetic protein-2 will be a novel biochemical marker in urinary tract infections and stone formation

Salama, Ragaa H. M.; Alghasham, Abdullah; Mostafa, Mohammed; Elmoniem, Alaa E. Abd

doi:10.1016/j.clinbiochem.2012.04.005

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…The increased risk of urinary complications may relate to rhBMP2’s ability to induce renal arterial fibrosis leading to glomerular epithelial cell damage, stasis, and followed by infection. 20 Further investigation outlining the pathophysiology in rhBMP2-associated complications may merit better contraindication protocols and improve rhBMP2’s complication profile; this would simplify the discussion of rhBMP2’s clinical utility to one of fusion efficacy.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion

Esmail

Buser

Cohen

et al. 2017

Global Spine Journal

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Study Design:Retrospective database review.Objective:Posterior/posterolateral lumbar fusion (PLF) is an effective treatment for a variety of spinal disorders; however, variations in surgical technique have different complication profiles. The aim of our study was to quantify the frequency of various complications in patients undergoing PLF with and without human recombinant bone morphogenetic protein 2 (rhBMP2).Methods:We queried the orthopedic subset of the Medicare database (PearlDiver) between 2005 and 2011 for patients undergoing PLF procedures with and without rhBMP2. Complication and reoperation rates were analyzed within 1 year of the index procedure. Complications assessed include: acute renal failure, deep vein thrombosis, dural tear, hematoma, heterotopic ossification, incision and drainage, cardiac complications, nervous system complications, osteolysis, pneumonia, pseudarthrosis, pulmonary embolism, radiculopathy, respiratory complications, sepsis, urinary retention, urinary tract infection, mechanical, and wound complications. Chi-square analysis was used to calculate the complication differences between the groups.Results:Our data revealed higher overall complication rates in patients undergoing PLF with rhBMP2 versus no_rhBMP2 (76.9% vs 68.8%, P < .05). Stratified by gender, rhBMP2 males had higher rates of mechanical complications, pseudarthrosis, and reoperations compared with no_rhBMP2 males (P < .05), whereas rhBMP2 females had higher rates of pseudarthrosis, urinary tract infection, and urinary retention compared with no_rhBMP2 females (P < .05).Conclusion:Our data revealed higher overall complication rates in PLF patients given rhBMP2 compared with no_rhBMP2. Furthermore, our data suggests that rhBMP2-associated complications may be gender specific.

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Section: Discussionmentioning

confidence: 99%

Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion

Esmail

Buser

Cohen

et al. 2017

Global Spine Journal

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“…[127] Stone patients excrete lower amounts of fetuin-A,[135] and more BMP-2. [136] Single nucleotide polymorphism of MGP gene is associated with CaOx kidney stones disease in the Japanese [137] and Chinese populations. [138]…”

Section: Regulation Of Randall’s Plaque Formationmentioning

confidence: 99%

Unified theory on the pathogenesis of Randall’s plaques and plugs

2014

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Kidney stones develop attached to sub-epithelial plaques of calcium phosphate (CaP) crystals (termed Randall’s plaque) and/or form as a result of occlusion of the openings of the Ducts of Bellini by stone forming crystals (Randall’s plugs). These plaques and plugs eventually extrude into the urinary space, acting as a nidus for crystal overgrowth and stone formation. To better understand these regulatory mechanisms and the pathophysiology of idiopathic calcium stone disease, this review provides in-depth descriptions of the morphology and potential origins of these plaques and plugs, summarizes existing animal models of renal papillary interstitial deposits, and describes factors that are believed to regulate plaque formation and calcium overgrowth. Based on evidence provided within this review and from the vascular calcification literature, we propose a “unified” theory of plaque formation – one similar to pathological biomineralization observed elsewhere in the body. Abnormal urinary conditions (hypercalciuria, hyperoxaluria, hypocitraturia), renal stress or trauma, and perhaps even the normal aging process leads to transformation of renal epithelial cells into an osteblastic phenotype. With this de-differentiation comes an increased production of bone specific proteins (i.e. osteopontin), a reduction in crystallization inhibitors (such as fetuin and matrix-gla-protein), and creation of matrix vesicles, which support nucleation of CaP crystals. These small deposits promote aggregation and calcification of surrounding collagen. Mineralization continues by calcification of membranous cellular degradation products and other fibers until the plaque reaches the papillary epithelium. Through the activity of matrix metalloproteinases or perhaps by brute physical force produced by the large subepithelial crystalline mass, the surface is breached and further stone growth occurs by organic matrix-associated nucleation of CaOx or by the transformation of the outer layer of CaP crystals into CaOx crystals. Should this theory hold true, developing an understanding of the cellular mechanisms involved in progression of a small, basic interstitial plaque to that of an expanding, penetrating plaque could assist in the development of new therapies for stone prevention.

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“…Bone morphogenetic protein-2 (BMP-2) is known for its important role in the development of bone and cartilage, but it seems to participate in the paracrine and autocrine action of organ regeneration [49]. Only one study investigated its role in UTI diagnosis and showed a significant increase in its serum levels in UTIs [50].…”

Section: Bone Morphogenetic Protein-2mentioning

confidence: 99%

Asymptomatic Bacteriuria or Urinary Tract Infection? New and Old Biomarkers

Martino

Novara

2022

IJTM

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Urinary tract infections (UTIs) are among the most common infective disease in the adult population. UTI diagnosis is based essentially on the presence of lower urinary tract symptoms (e.g., dysuria, urgency, and frequency) and the evidence of bacteriuria (by dipstick testing and/or urine culture). UTI diagnosis is not always easy because symptoms can be vague, or patient basal conditions can interfere negatively with the diagnostic process, whereas urine culture is still ongoing. In those cases, the differential diagnosis among UTIs and asymptomatic bacteriuria (ABU) may be challenging, while the clinician has to decide whether to start an antibiotic treatment shortly. The purpose of the present review is to analyze the biomarkers that could help in UTI diagnosis. Some biomarkers, such as procalcitonin, interleukin-6, neutrophil gelatinase-associated lipocalin, chemokines, lactoferrin, and bone morphogenetic protein-2, seem promising in UTI diagnosis, while other biomarkers failed to show any utility. Whereas a single biomarker was not enough, a combination of biomarkers could have more chances to help in the diagnosis.

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Bone morphogenetic protein-2 will be a novel biochemical marker in urinary tract infections and stone formation

Cited by 11 publications

References 20 publications

Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion

Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion

Unified theory on the pathogenesis of Randall’s plaques and plugs

Asymptomatic Bacteriuria or Urinary Tract Infection? New and Old Biomarkers

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