Bone morphogenetic protein (BMP)-modified graphene oxide-reinforced polycaprolactone–gelatin nanofiber scaffolds for application in bone tissue engineering

Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review

“… 95 Recently, Kadhim et al reinforced polycaprolactone (PCL)–gelatin nanofiber scaffolds using bone morphogenetic protein (BMP)-modified GO. 96 In this case, although gelatin has favorable biological properties, it does not possess good mechanical stability, and therefore it was combined with PCL and GO to achieve the desired mechanical properties. Comparing the mechanical properties of gel/PCL and gel/PCL–GO–BMP (2.5 wt% GO) proved that the ultimate tensile strength increased from 8.5 ± 0.3 MPa to 17.2 ± 0.3 MPa, but the strain at break was reduced from 116% ± 6.2% to 90% ± 2.9% due to its high stiffness.…”