Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus)

Characteristics of newly‐formed cementum following emdogain application

“…Recent studies of GTR also suggested that the formation of these artifacts did not depend on whether or not the root surfaces had been exposed surgically [33] or were exposed as a result of periodontitis [31,34]. Separation of regenerative cementum from the underlying dentin could not be prevented by the employment of growth and differentiation factors [35][36]. At the ultrastructural level, it was showed that artifact splits were microscopically associated with the presence of an electron-dense, granular, and non-collagenous layer at the interface between old and new tissue [30,37].…”

Recombinant Human Plasminogen Activator Inhibitor-1 Promotes Cementogenic Differentiation of Human Periodontal Ligament Stem Cells

“…Previous reports have demonstrated that xenogenic bone graft and growth factors, including transforming growth factor-beta (TGF-b), bone morphogenetic protein (BMP)-2, BMP-4, and platelet-derived growth factor (PDGF), improve periodontal tissue regeneration. [41][42][43][44] MSC transplantation can supply large numbers of necessary cells and increase periodontal regenerative capacity. 45,46 It also well known that MSCs can differentiate into the desired tissues, such as cementum, alveolar bone, dentin, and collagen fibers.…”

Implications of cellular and molecular biology advances in periodontal regeneration

“…Recently, BMP's were used in animal studies in an attempt to promote periodontal regeneration. Surgically created periodontal wound defects treated with BMP-2 or osteogenin, in beagles (Sigurdsson et al, 1995) or baboon (Ripamonti et al, 1994) significantly enhanced periodontal regeneration. These studies provide the first evidence that exogenous growth factors can supplement endogenous ones to participate in the healing cascades leading to the expression of tissue-specific phenotypes associated with periodontal regeneration.…”