Bone–muscle crosstalk following exercise plus Ursolic acid by myomiR-133a/Cx43-Runx2 axis in aged type 2 diabetes rat models

Farsani, Maryam Asadi; Banitalebi, Ebrahim; Faramarzi, Mohammad; Bakhtiari, Nuredin; Rahimi, Mostafa; Duque, Gustavo

doi:10.1016/j.cbi.2022.110315

Cited by 1 publication

(1 citation statement)

References 45 publications

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“…Lifestyle interventions, self-management, and education need to be pursued in all patients (Figure 1) with the aim of facilitating knowledge on the skeletal complications of T2DM, assessing fracture risk (according to guidelines [2]) and promoting physical activity to improve postural stability, reduce risk of fall, and ameliorate BMD and bone Lifestyle interventions, self-management, and education need to be pursued in all patients (Figure 1) with the aim of facilitating knowledge on the skeletal complications of T2DM, assessing fracture risk (according to guidelines [2]) and promoting physical activity to improve postural stability, reduce risk of fall, and ameliorate BMD and bone quality [95]. Pre-clinical and clinical studies demonstrated the beneficial effects of exercise training on bone metabolism in rat models and in patients with T2DM [99,100]. In particular, increases in bone turnover in association with improvement in glycemic control and decreased body weight and fat mass were observed in diabetic patients, as well as the maintenance of BMD regardless of lower body weight even in older adults [101].…”

Section: The Use Of Antidiabetics In T2dm With and Without Ckd: From ...mentioning

confidence: 99%

Effect of Antidiabetic Drugs on Bone Health in Patients with Normal Renal Function and in Chronic Kidney Disease (CKD): Insight into Clinical Challenges in the Treatment of Type 2 Diabetes

Cipriani,

Lauriero,

Tripepi

et al. 2023

JCM

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Among the metabolic changes occurring during the course of type 2 diabetes (T2DM) and diabetic kidney disease (DKD), impaired bone health with consequent increased fracture risk is one of the most complex and multifactorial complications. In subjects with diabetic kidney disease, skeletal abnormalities may develop as a consequence of both conditions. In the attempt to define a holistic approach to diabetes, potential effects of various classes of antidiabetic drugs on the skeleton should be considered in the setting of normal kidney function and in DKD. We reviewed the main evidence on these specific topics. Experimental studies reported potential beneficial and harmful effects on bone by different antidiabetics, with few data available in DKD. Clinical studies specifically designed to evaluate skeletal effects of antidiabetics have not been performed; notwithstanding, data gleaned from randomized controlled trials and intervention studies did not completely confirm observations made by basic research. In the aggregate, evidence from meta-analyses of these studies suggests potential positive effects on fracture risk by metformin and glucagon-like peptide-1 receptor agonists, neutral effects by dipeptidyl peptidase-4 inhibitors, sodium–glucose cotransporter-2 inhibitors, and sulfonylureas, and negative effects by insulin and thiazolidinediones. As no clinical recommendations on the management of antidiabetic drugs currently include fracture risk assessment among the main goal of therapy, we propose an integrated approach with the aim of defining a patient-centered management of diabetes in chronic kidney disease (CKD) and non-CKD patients. Future clinical evidence on the skeletal effects of antidiabetics will help in optimizing the approach to a personalized and more effective therapy of diabetes.

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Section: The Use Of Antidiabetics In T2dm With and Without Ckd: From ...mentioning

confidence: 99%

Effect of Antidiabetic Drugs on Bone Health in Patients with Normal Renal Function and in Chronic Kidney Disease (CKD): Insight into Clinical Challenges in the Treatment of Type 2 Diabetes

Cipriani,

Lauriero,

Tripepi

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Bone–muscle crosstalk following exercise plus Ursolic acid by myomiR-133a/Cx43-Runx2 axis in aged type 2 diabetes rat models

Cited by 1 publication

References 45 publications

Effect of Antidiabetic Drugs on Bone Health in Patients with Normal Renal Function and in Chronic Kidney Disease (CKD): Insight into Clinical Challenges in the Treatment of Type 2 Diabetes

Effect of Antidiabetic Drugs on Bone Health in Patients with Normal Renal Function and in Chronic Kidney Disease (CKD): Insight into Clinical Challenges in the Treatment of Type 2 Diabetes

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