Bone or pleura? Primary pleural osteosarcoma

Chandak, Pankaj; Hunt, Ian; Rawlins, R.; Lucas, Sebastian; Treasure, Tom

doi:10.1016/j.jtcvs.2006.09.050

Cited by 12 publications

(6 citation statements)

References 5 publications

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“…32,46,47 However, even recent reports of extraskeletal oesteosarcoma, one in a 73-year-old patient with known exposure to asbestos and another of a 76-year-old Navy engineer (with no data regarding asbestos exposure available), make no mention of immunohistochemical studies that might have suggested a diagnosis of mesothelioma. 48,49 Heterologous elements have rarely been described in other primary pleural sarcomas, such as malignant fibrous histiocytoma and malignant nerve sheath tumour. 50 We are not aware of pleural synovial sarcoma showing heterologous differentiation, but knowledge of the anatomical distribution and molecular studies demonstrating the SYT-SSX fusion gene would be helpful in that instance.…”

Section: Differential Diagnosis and Role Of Immunohistochemical Studiesmentioning

confidence: 99%

Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review

et al. 2008

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Only a small number of malignant mesotheliomas with heterologous elements have been described. There are currently no criteria for diagnosis and little data regarding prognosis. We suggest that the term heterologous mesothelioma should be reserved for tumours that show malignant heterologous elements, notably osteosarcomatous, chondrosarcomatous, or rhabdomyoblastic elements but have immunohistochemical and clinical characteristics of mesothelioma. We identified 27 such cases and characterized the clinical and pathological characteristics of these tumours. In our series, 89% originated in the pleura, and 11% from the peritoneal cavity. The median age at diagnosis was 68 years, ranging from 27 to 85 years. Of these cases, 93% occurred in males and 7% in women. Of the 27 mesothelioma cases 16 (59%) were sarcomatoid, 10 (37%) were biphasic, and one was reported as epithelioid; 40% (11 cases) showed osteosarcomatous elements only, 19% showed areas of rhabdomyosarcoma only, 19% contained areas of chondrosarcoma only, and 22% exhibited osteochondromatous elements. Immunohistochemical labelling for cytokeratins was present in the majority of cases. Exposure to asbestos was identified in all the 17 cases for which an exposure history was available (63%). Median survival was 6 months after diagnosis, similar to the survival seen in sarcomatoid mesotheliomas. The differential diagnosis includes primary and secondary pleural sarcomas, including osteosarcomas and chondrosarcomas. Immunohistochemical labelling for cytokeratins is helpful in the distinction, but lack of labelling for cytokeratins in a spindle cell/sarcomatoid tumour does not exclude the diagnosis of mesothelioma, irrespective of the presence of heterologous elements. We suggest that if the anatomical distribution conforms to that of mesothelioma, a diagnosis of heterologous mesothelioma should be made in preference to a diagnosis of primary pleural osteosarcoma or chondrosarcoma, regardless of cytokeratin positivity, as for conventional non-heterologous sarcomatoid mesothelioma.

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Section: Differential Diagnosis and Role Of Immunohistochemical Studiesmentioning

confidence: 99%

Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review

et al. 2008

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“…To our knowledge, only four cases of pleural osteosarcoma have ever been previously reported. [2][3][4][5] Here we present the case of a 64-yearold Japanese man with extraskeletal chondroblastic osteosarcoma that originally had arisen from the pleura. Both clinical and radiographic evaluations failed to reveal any tumor at other sites.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] All of these cases were male. The onset age of such patients was the sixth to seventh decade of life, in contrast to skeletal osteosarcoma, in which the peak incidence tends to be in the second decade of life.…”

Section: Discussionmentioning

confidence: 99%

Chondroblastic osteosarcoma arising from the pleura: Report of a case

et al. 2009

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Extraskeletal osteosarcoma is an uncommon malignant neoplasm. The origin of osteosarcoma in the pleura is extremely rare, with only four such cases so far documented in the literature to the best of our knowledge. We herein report the case of a 64-year-old Japanese man in whom a left pneumonectomy and pleurectomy were carried out to remove a huge tumor. The pathological examination confirmed a diagnosis of chondroblastic osteosarcoma that had originally arisen from the pleura.

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“…1 Among the various known types of extraskeletal osteosarcoma, only a few reports concerning primary pleural osteosarcoma were found. 3,4 We herein present an exceedingly rare case of pleural osteosarcoma occurring in a patient over 70 years of age.…”

Section: Introductionmentioning

confidence: 95%

Extraskeletal osteosarcoma of the pleura: a case report

Matono

Maruyama

Ide

et al. 2008

Gen Thorac Cardiovasc Surg

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We herein present an exceedingly rare case of pleural osteosarcoma that was surgically resected in an elderly patient. A 74-year-old man, complaining of a dry cough and breathlessness on effort, was found to have massive pleural effusion on a chest X-ray. The chest CT and MRI scans indicated a massive effusion and a pleural tumor encasing the left lower lung. The resected tumor was histologically an osteosarcoma, measuring 11.3 x 9.0 x 6.0 cm. Because there was no evidence of any other primary tumor, the diagnosis of extraskeletal osteosarcoma was appropriate.

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Bone or pleura? Primary pleural osteosarcoma

Abstract: Figure 2. Histologic examination demonstrated pink islands of osteoid with malignant cells showing atypical mitosis. There was no identifiable epithelial component and no mesothelioma.

Cited by 12 publications

References 5 publications

Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review

Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review

Chondroblastic osteosarcoma arising from the pleura: Report of a case

Extraskeletal osteosarcoma of the pleura: a case report

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