Bone perfusion and oxygenation

Kiaer, T

doi:10.3109/17453679409155653

Acta Orthopaedica Scandinavica

1994

DOI: 10.3109/17453679409155653

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Bone perfusion and oxygenation

T Kiaer

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1996

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Cited by 13 publications

References 156 publications

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A nonlinear model for myogenic regulation of blood flow to bone: Equilibrium states and stability characteristics

Harrigan¹

1996

Ann Biomed Eng

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A simple compartmental model for myogenic regulation of interstitial pressure in bone is developed, and the interaction between changes in interstitial pressure and changes in arterial and venous resistance is studied. The arterial resistance is modeled by a myogenic model that depends on transmural pressure, and the venous resistance is modeled by using a vascular waterfall. Two series capacitances model blood storage in the vascular system and interstitial fluid storage in the extravascular space. The static results mimic the observed effect that vasodilators work less well in bone than do vasoconstrictors. The static results also show that the model gives constant flow rates over a limited range of arterial pressure. The dynamic model shows unstable behavior at small values of bony capacitance and at high enough myogenic gain. At low myogenic gain, only a single equilibrium state is present, but a high enough myogenic gain, two new equilibrium states appear. At additional increases in gain, one of the two new states merges with and then separates from the original state, and the original state becomes a saddle point. The appearance of the new states and the transition of the original state to a saddle point do not depend on the bony capacitance, and these results are relevant to general fluid compartments. Numerical integration of the rate equations confirms the stability calculations and shows limit cycling behavior in several situations. The relevance of this model to circulation in bone and to other compartments is discussed.

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A nonlinear model for myogenic regulation of blood flow to bone: Equilibrium states and stability characteristics

Harrigan¹

1996

Ann Biomed Eng

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Update on MRI findings of osteomyelitis of long bones in the adult population

et al. 2022

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Contribution of Circulatory Disturbances in Subchondral Bone to the Pathophysiology of Osteoarthritis

2017

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MRI and PET have revealed that venous outflow obstruction results in physicochemical changes in subchondral bone to which osteoblasts are responsive. The osteoblasts express an altered pattern of cytokines, many of which can serve as structural or signaling molecules contributing to both bone remodeling and cartilage degeneration. The patterns of circulatory changes are associated with alterations in the physicochemical environment of subchondral bone, including hypoxia. Osteoblast cytokines can transit the subchondral bone plate and calcified cartilage and communicate with chondrocytes.

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Bone perfusion and oxygenation

Cited by 13 publications

References 156 publications

A nonlinear model for myogenic regulation of blood flow to bone: Equilibrium states and stability characteristics

A nonlinear model for myogenic regulation of blood flow to bone: Equilibrium states and stability characteristics

Update on MRI findings of osteomyelitis of long bones in the adult population

Contribution of Circulatory Disturbances in Subchondral Bone to the Pathophysiology of Osteoarthritis

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