Bone regeneration by calcium phosphate‐loaded carboxymethyl cellulose nonwoven sheets in canine femoral condyle defects

Abstract

The bone regeneration capacities of calcium phosphate (CaP)‐loaded carboxymethyl cellulose (CMC) nonwoven sheet (CMC/CaP) were evaluated using a dog lateral femoral condyle defect model. In addition, the effect of bFGF on bone regeneration when added to CMC/CaP sheet was investigated. The CMC and CMC/CaP sheets have high operability. The new bone formation rate in the CMC/CaP group was significantly higher than that in the control and CMC groups based on micro‐computed tomography and histological evaluation. In contrast, there was no significant difference between the CMC/CaP group and the CMC/CaP/f group. In conclusion, the CMC/CaP sheet has the ability to promote new bone formation and seems to be useful as a sheet‐shaped bone graft substitute. The effect of the auditioning signaling molecules to the CMC/CaP sheet, such as bFGF, requires further investigation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1516–1521, 2019.

Biodegradable Polymers in Veterinary Medicine—A Review

“…An effective neoformation of a vascular wall structure along the BC scaffolds was observed, and the immigration of vascular smooth muscle cells into the synthetic matrix, without signs of inflammatory potential. The results confirm that the BC grafts provide stable vascular conduits promoting the neoformation of a vascular wall and are promising materials for future innovative programs for vascular surgery [ 121 , 124 , 125 ]. Moreover, their great potential for coronary and peripheral bypass grafting in pigs was also confirmed [ 126 ].…”

The Balance between the Hemostatic Effect and Immune Response of Hyaluronan Conjugated with Different Chain Lengths of Inorganic Polyphosphate

“…PolyPs and HA-PolyPs indicated the interesting differences in acute inflammation and coagulation in the present research. Although the biological functions of PolyP have been eagerly investigated − for more than a century since the discovery of PolyP in yeast in 1890, further research is expected in PolyP and PolyP-based bioconjugates or biomaterials. Our results clarified unique properties of short-chain PolyPs and provide potential for the development of PolyP and PolyP-based biomaterials, bioconjugates, and bio-macromolecules for medical applications.…”

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

“…As one of the most abundant polysaccharides, cellulose may be derived from either plants or bacteria and is investigated together with its derivatives like carboxymethylcellulose (CMC) as matrix material due to its inherent biocompatibility and biodegradability [126]. Combinations with different CaPs like HA [127][128][129][130], CDHA [131], CPC [132], and BCP [133][134][135] are recently evaluated for bone tissue regeneration.…”

“…However, there was no significant difference between CaP-loaded scaffolds with or without bFGF. Thus, bone regenerating properties of the mineralized scaffolds are attributed to the gradual release of calcium and phosphate ions in the defect site [134]. Reproduced from work in [128] with permission from Springer Nature, 2019.…”