Bone regeneration in dehiscence‐type defects at chemically modified (SLActive^®) and conventional SLA titanium implants: a pilot study in dogs

Abstract

Within the limits of the present study, it was concluded that modSLA titanium surfaces may promote bone regeneration in acute-type buccal dehiscence defects at submerged implants.

Clinical Evaluation of Anodized Surface Implants Submitted to a Counter Torque of 25 Ncm After 60 Days of Osseointegration: Study in Humans

“…Superficial changes with bisphosphonates and collagen seem to precociously reinforce peri-implant bone formation [12,18,19], and they improve cicatrization in the first 5 weeks [30]. To diminish osseointegration time, thus altering the biological behavior of implant, it is necessary to maintain the implant in an isotonic surface to eliminate the titanium oxide layer [31][32][33]. Maintaining both the implant and those surfaces bio-activated by bisphosphonates in an isotonic solution in animals presented significant differences in neither the quantity of bone formation nor the percentage of bone/implant contact [34].…”

“…In humans, 2 months following implant placement, the surface presented greater bone/implant contact than machined surface implants [35]. There are many works in the relevant literature on animals that address the aspect of speed of osseointegration on bioactive surfaces [14,18,31,[36][37][38], but there are few works on humans defining the necessary amount of time needed before placing a load on such implants [3]. Therefore, in this study, we chose to verify the secondary stability of implants produced by the company Connection, using a Vulcano surface (anodization) in humans.…”

Soft Tissue Biology and Management in Implant Dentistry

“…The release into the market place of two dental implants with "bioactive" surface has not met with resounding success. (Cooper, Zhou et al 2006;Schwarz, Herten et al 2007;Junker, Dimakis et al 2009). Clearly, the industry-driven effort in improving the engineering aspect of implant development will continue at a rapid pace.…”

Reality of Dental Implant Surface Modification: A Short Literature Review

“…Several studies have evaluated the biocompatibility of an SLA surface with additional modifications aimed to increase hydrophilicity [53][54][55]. These studies indicated that such a hydrophilic SLA surface promotes bone formation and shows increased osteogenic potential, when compared to its predecessor, an SLA surface with no modifications to hydrophilic properties [53][54][55][56]. The hydrophilic SLA surface was reported to have a positive influence on early bone response in a previous study that used dogs, showing higher bone-to-implant contact than the conventional, non-hydrophilic SLA (hydrophobic SLA) surface [53].…”

“…An in vitro experiment with human bone marrow-derived mesenchymal stromal cells showed higher gene expression levels of the osteogenic markers like runt-related transcription factor 2 (RUNX2) and bone sialoprotein (BSP) on the hydrophilic SLA surface [55]. The authors of those studies interpreted the data to indicate that hydrophilicity improves biocompatibility of the SLA surface to the implant during osseointegration [53][54][55][56]. At the in vitro level, bone cell adhesion is higher on the hydrophilic SLA surface than on the anodized or calcium phosphate-coated surface [57].…”