2008
DOI: 10.1016/j.ijom.2008.07.012
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Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology

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Cited by 66 publications
(51 citation statements)
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“…PGA and PLA are degradable, and their degradation product is weakly acidic. The acid-base neutralization reaction that occurs locally during degradation can prevent aseptic inflammation, maintain acid-base balance and promote osteogenesis (16). Zhou (7) demonstrated that physiological repair of defects in articular cartilage and the corresponding subchondral bone was achievable using autologous BMSCs and PGA/PLA polymers.…”
Section: Discussionmentioning
confidence: 99%
“…PGA and PLA are degradable, and their degradation product is weakly acidic. The acid-base neutralization reaction that occurs locally during degradation can prevent aseptic inflammation, maintain acid-base balance and promote osteogenesis (16). Zhou (7) demonstrated that physiological repair of defects in articular cartilage and the corresponding subchondral bone was achievable using autologous BMSCs and PGA/PLA polymers.…”
Section: Discussionmentioning
confidence: 99%
“…PLGA scaffolds were used to repair defects of other tissues such as bone [68,71,[76][77][78], liver [79], nerve [66,80], skin [81] and blood vessel [69,82]. Drugs or proteins especially growth factors or genes to express growth factors were also loaded into porous scaffolds, which could significantly improve the regeneration of new tissues [12,55,75,83,84].…”
Section: Tissue Repair and Reconstruction Based On Poly(lactide-co-glmentioning
confidence: 99%
“…However, the intrinsic and uncontrolled brittleness is generally encountered in the current β-TCP-based porous scaffolds, which hampers their applications, especially as load-bearing implants for bone regeneration [6]. To address this drawback, the combination of biodegradable polymers, such as polylactic acid (PLA) [7], polycaprolactone (PCL) [8,9], and poly (lactic-co-glycolic acid) (PLGA) [9], has been applied to create composite biomaterials. By the traditional facile mixing method, a variety of hybridized composites composed of polymer matrix and small fraction (no more than 40 vol.%) of ceramic component as dispersed phase have been successfully fabricated.…”
Section: Introductionmentioning
confidence: 99%