Bone regeneration with hydroxyapatite-based biomaterials

Bal, Zeynep; Kaito, Takashi; Korkusuz, Feza; Yoshikawa, Hideki

doi:10.1007/s42247-019-00063-3

Cited by 132 publications

(80 citation statements)

References 181 publications

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“…As an implant, HA has good stability, biocompatibility, and degradability. HA can not only promote the adhesion, proliferation of osteoblasts, and extracellular matrix secretion, but also form chemical bonds with the body’s own bones [ 18 , 19 , 20 ]. Therefore, it has the effect of repairing bone defects.…”

Section: Introductionmentioning

confidence: 99%

A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

Wang

Cao

et al. 2020

Materials

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A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca2+ from nHA can form a [HO]Ca2+ [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.

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Section: Introductionmentioning

confidence: 99%

A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

Wang

Cao

et al. 2020

Materials

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“…The composition of BCP make it ideal for bone regeneration, as the HA provides volume stability, whilst the β-TCP drives a bioactive response with its more rapid degradation [ 38 ]. It is similar to natural apatite, which is the main mineral constitute of human bone and is the main structural component that provides its rigidity [ 39 ]. With a high rate of osseointegration and volume stability, it can produce regenerative results comparable to xenografts [ 7 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…In total, a significant effect of 15% or more would be of interest. Considering previous rates for macrophage induction and new bone formation in the control group and biomaterial group(s) with significances of minimally 0.05 and power levels in accordance to the web site (accessed on 25 March 2021), both study parts have considered to require a number of five animals per material/treatment and post-operative time point [ 39 , 48 , 70 , 71 , 72 , 73 , 74 ].…”

Section: Methodsmentioning

confidence: 99%

Ex Vivo and In Vivo Analyses of Novel 3D-Printed Bone Substitute Scaffolds Incorporating Biphasic Calcium Phosphate Granules for Bone Regeneration

Oberdiek¹,

Vargas

Rider³

et al. 2021

IJMS

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(1) Background: The aim of this study was examining the ex vivo and in vivo properties of a composite made from polycaprolactone (PCL) and biphasic calcium phosphate (BCP) (synprint, ScientiFY GmbH) fabricated via fused deposition modelling (FDM); (2) Methods: Scaffolds were tested ex vivo for their mechanical properties using porous and solid designs. Subcutaneous implantation model analyzed the biocompatibility of PCL + BCP and PCL scaffolds. Calvaria implantation model analyzed the osteoconductive properties of PCL and PCL + BCP scaffolds compared to BCP as control group. Established histological, histopathological and histomorphometrical methods were performed to evaluate new bone formation.; (3) Results Mechanical testing demonstrated no significant differences between PCL and PCL + BCP for both designs. Similar biocompatibility was observed subcutaneously for PCL and PCL + BCP scaffolds. In the calvaria model, new bone formation was observed for all groups with largest new bone formation in the BCP group, followed by the PCL + BCP group, and the PCL group. This finding was influenced by the initial volume of biomaterial implanted and remaining volume after 90 days. All materials showed osteoconductive properties and PCL + BCP tailored the tissue responses towards higher cellular biodegradability. Moreover, this material combination led to a reduced swelling in PCL + BCP; (4) Conclusions: Altogether, the results show that the newly developed composite is biocompatible and leads to successful osteoconductive bone regeneration. The new biomaterial combines the structural stability provided by PCL with bioactive characteristics of BCP-based BSM. 3D-printed BSM provides an integration behavior in accordance with the concept of guided bone regeneration (GBR) by directing new bone growth for proper function and restoration.

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“…Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 —abbr. HAp) is used in medicine as a bone implant material due to its biocompatibility, bioactivity, and similarity to bone mineral [ 3 , 4 ]. However, it is still widely investigated in order to improve its properties by obtaining appropriate grain size, morphology, mechanical strength, and solubility and by adding some dopants that are, e.g., naturally built into bone apatite, ions possessing antibacterial properties, or ions enabling bio-imaging [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection

et al. 2021

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The hydroxyapatite nanopowders of the Eu3+-doped, Cu2+-doped, and Eu3+/Cu2+-co-doped Ca10(PO4)6(OH)2 were prepared by a microwave-assisted hydrothermal method. The structural and morphological properties of the products were investigated by X-ray powder diffraction (XRD), transmission electron microscopy techniques (TEM), and infrared spectroscopy (FT-IR). The average crystal size and the unit cell parameters were calculated by a Rietveld refinement tool. The absorption, emission excitation, emission, and luminescence decay time were recorded and studied in detail. The 5D0 → 7F2 transition is the most intense transition. The Eu3+ ions occupied two independent crystallographic sites in these materials exhibited in emission spectra: one Ca(1) site with C3 symmetry and one Ca(2) sites with Cs symmetry. The Eu3+ emission is strongly quenched by Cu2+ ions, and the luminescence decay time is much shorter in the case of Eu3+/Cu2+ co-doped materials than in Eu3+-doped materials. The luminescence quenching mechanism as well as the schematic energy level diagram showing the Eu3+ emission quenching mechanism using Cu2+ ions are proposed. The electron paramagnetic resonance (EPR) technique revealed the existence of at least two different coordination environments for copper(II) ion.

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Bone regeneration with hydroxyapatite-based biomaterials

Cited by 132 publications

References 181 publications

A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

Ex Vivo and In Vivo Analyses of Novel 3D-Printed Bone Substitute Scaffolds Incorporating Biphasic Calcium Phosphate Granules for Bone Regeneration

Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection

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