2018
DOI: 10.1093/omcr/omx110
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Bone relapse in T-lineage acute lymphoblastic leukemia in a child

Abstract: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. T-cell ALL accounts for 10–15% of cases. ALL can rarely relapse in unusual extramedullary sites like bone. Hereby, we report a case of 7-year-old male child who was being treated for T-cell ALL and then presented with left arm swelling. This swelling was initially thought to be a bone tumor but later it was found to be infiltrated by leukemic blasts. We reviewed all previous cases and suggest that in a patient of ALL presenting with … Show more

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Cited by 3 publications
(5 citation statements)
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“…T-ALL presented a higher risk of relapsing compared to B-ALL in the univariate analysis—a fact that is in accordance with the known published literature ( 17 , 18 ). Nonetheless, this is not kept in the multivariate model, showing that, in our experience, FCM-MRD and prednisone can overrule the immunophenotype.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…T-ALL presented a higher risk of relapsing compared to B-ALL in the univariate analysis—a fact that is in accordance with the known published literature ( 17 , 18 ). Nonetheless, this is not kept in the multivariate model, showing that, in our experience, FCM-MRD and prednisone can overrule the immunophenotype.…”
Section: Discussionsupporting
confidence: 91%
“…Nonetheless, this is not kept in the multivariate model, showing that, in our experience, FCM-MRD and prednisone can overrule the immunophenotype. Immunological classification is not to be removed from the clinical management considering the different biology of these diseases and, thus, different therapeutic management ( 17 , 18 ).…”
Section: Discussionmentioning
confidence: 99%
“…In our case, the patient presented new clone, after the period of induction ( 5 ). Usually, medullary relapse is associated with unfavorable prognosis and requires aggressive chemotherapy followed by bone marrow transplantation ( 6 ).…”
Section: Discussionmentioning
confidence: 99%
“…We report a case of an extremely rare and early occurrence of extramedullary ALL relapse, a peripheral bone involvement. Reviewing the literature, only a handful of reports are available regarding this topic [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. In 12 out of the 15 paediatric cases featured, subsequent bone marrow or central nervous system relapse was observed, with eventual death in seven of these.…”
Section: Discussionmentioning
confidence: 99%
“…Isolated extramedullary relapse of leukaemia in the skeletal system, though an extremely rare phenomenon, is a matter of greater concern. There is a limited number of case reports regarding this topic [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. In 1994, Murray et al reviewed the available reports at that time and made several important observations [ 7 ].…”
Section: Introductionmentioning
confidence: 99%