Bone repair cells for craniofacial regeneration

Pagni, Giorgio; Kaigler, Darnell; Rasperini, Giulio; Ávila‐Ortiz, Gustavo; Bartel, Ronnda L.; Giannobile, William V.

doi:10.1016/j.addr.2012.03.005

Cited by 78 publications

(91 citation statements)

References 165 publications

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“…Therefore, successful repair and regeneration of the bone structures, such as alveolar bone, bone in temporomandibular area, and other joints will produce promising results in management of craniofacial conditions. 15,16 Bone morphogenetic proteins (BMPs) play an important role during active bone formation in embryogenesis, growth of bony structures, and probably healing of fractured bone. Among these, BMPs 2, 4, and 7 can induce de novo bone formation both in vitro and at heterotopic sites.…”

Section: Applications In Dentistrymentioning

confidence: 99%

Gene Therapy as a Management Tool in Dentistry

2017

International Journal of Advanced and Integrated Medical Sciences

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Introduction Gene therapy is an emerging field of biomedicine that has gained significant attention in dentistry too. Various research programs are being carried out to understand the cellular and molecular bases of every disease. Since most of the conventional therapeutic approaches are not so satisfactory in treating a disease completely, currently there is an increasing focus on gene therapy to treat a wide variety of inherited and acquired diseases. This new era of gene therapy can be accomplished in the medicine field primarily to replace or cure defective genes and treat a wide variety of gene disorders, whether the disease is due to single or multiple defective genes. It has a variety of applications in the field of dentistry like salivary gland disorders, autoimmune conditions, potentially malignant disorders, etc. The sites, such as minor salivary glands present in the labial and buccal mucosa and also mucosal keratinocytes are potential targets for gene therapy, since these structures are superficial and offer minimal hindrance to the gene therapy procedure. The present article discusses the basic principles of gene therapy, its applications in the field of dentistry, limitations, and disadvantages. How to cite this article Gupta P, Thakur J. Gene Therapy as a Management Tool in Dentistry. Int J Adv Integ Med Sci 2017;2(3):149-154.

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Section: Applications In Dentistrymentioning

confidence: 99%

Gene Therapy as a Management Tool in Dentistry

2017

International Journal of Advanced and Integrated Medical Sciences

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“…Despite advances in bone regeneration and the availability of many treatments, most clinicians and researchers continue to come to the same conclusion: autologous bone grafting remains the "gold standard," compared to other reconstructive procedures [4][5][6][7][8][9]. Bone from the same patient lacks immunogenicity and contains all the elements necessary to effectively induce tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, many times the volume of tissue available for the procedure is not sufficient to fill or cover a defect, given the limited availability of autologous tissue [4,10], and the quality of the autograft is highly variable and is influenced by age and metabolic abnormalities of the patient [7]. To overcome these limitations, a variety of exogenous substitutes, including allografts, xenografts and alloplastic materials, have been introduced into clinical practice in the past three decades [4].…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these limitations, a variety of exogenous substitutes, including allografts, xenografts and alloplastic materials, have been introduced into clinical practice in the past three decades [4]. However, these substitutes have less osteogenic and osteoinductive properties [6,12] and a greater possibility of transmission of infectious diseases [6,8], restricting their use [8].…”

Section: Introductionmentioning

confidence: 99%

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Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

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Bone defects are the cause of functional disability and the restoration of skeletal function remains an important challenge on orthopedics, neurosurgery and oral and maxillofacial surgery. Because of the limitations of the currently used techniques for the reconstruction of bone defects and the difficulties for the implementation of new therapeutic strategies, a new paradigm in the field of reconstructive surgery has arisen, leading to tissue engineering and regenerative medicine. Mesenchymal stem cells (MSC) have emerged as a promising alternative for the treatment of bone lesions. It was postulated that the therapeutic action was the result of proliferation and differentiation of MSCs, replacing injured tissue. However, recent studies have shown that MSCs secrete a number of trophic factors that have a strong effect during repair and tissue regeneration. This represents a shift from a paradigm centered on MSC proliferation and differentiation to a new paradigm in which the MSCs exert their beneficial effect by the secretion of paracrine factors that induce endogenous repair mechanisms. This chapter will bring together basic and clinical aspects, focused on novel findings on MSC paracrine effect and the development of new therapeutic strategies based on growth factors, cytokines and signaling molecules involved in bone regeneration.

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“…For regeneration and functioning restoration of destructed tissue complexes from injury, tumors, or trauma (Pagni et al, 2012), diverse conceptual microenvironments for growing tissues have been developed (Rehfeldt et al, 2007;Fu et al, 2010;Lee et al, 2010;Zemel et al, 2010;Bencherif et al, 2012;Guvendiren and Burdick, 2012;Mendes, 2013). However, there remains a need to better understand the 3-dimensional (3-D) orchestration of multicellular tissue formation (Burdick, 2009) as well as the relationship between engineered tissue complexes and native tissues/organs for functional restoration (Moffat et al, 2008;Park et al, 2010;Park et al, 2012).…”

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confidence: 99%

Spatiotemporally Controlled Microchannels of Periodontal Mimic Scaffolds

et al. 2014

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Physiologic bioengineering of the oral, dental, and craniofacial complex requires optimized geometric organizations of fibrous connective tissues. A computer-designed, fiber-guiding scaffold has been developed to promote tooth-supporting periodontal tissue regeneration and functional restoration despite limited printing resolution for the manufacture of submicron-scaled features. Here, we demonstrate the use of directional freeze-casting techniques to control pore directional angulations and create mimicked topographies to alveolar crest, horizontal, oblique, and apical fibers of natural periodontal ligaments. For the differing anatomic positions, the gelatin displayed varying patterns of ice growth, determined via internal pore architectures. Regardless of the freezing coordinates, the longitudinal pore arrangements resulted in submicron-scaled diameters (~50 µm), along with corresponding high biomaterial porosity (~90%). Furthermore, the horizontal + coronal ([Formula: see text]) freezing orientation facilitated the creation of similar structures to major fibers in the periodontal ligament interface. This periodontal tissue-mimicking microenvironment is a potential tissue platform for the generation of naturally oriented ligamentous tissues consistent with periodontal ligament neogenesis.

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Bone repair cells for craniofacial regeneration

Cited by 78 publications

References 165 publications

Gene Therapy as a Management Tool in Dentistry

Gene Therapy as a Management Tool in Dentistry

Regenerative Medicine: A New Paradigm in Bone Regeneration

Spatiotemporally Controlled Microchannels of Periodontal Mimic Scaffolds

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