Bone Repair Following Recombinant Human Bone Morphogenetic Protein‐2 Stimulated Periodontal Regeneration

Abstract

rhBMP-2/ACS elicits a rapid osteoinductive process throughout the implant as well as along and onto the instrumented adjacent root surface. Lamellated trabecular bone was the predominant regenerated tissue. A typical cementum-periodontal ligament-alveolar bone relationship was a rare observation. The great variability in histological tissue response along the instrumented root surface indicates that the stimulus to hard tissue formation resided primarily in the rhBMP-2/ACS implant rather than in the root surface.

Recombinant Biglycan Promotes Bone Morphogenetic Protein-induced Osteogenesis

“…To regenerate bone, an approach of tissue engineering has been developed consisting of a biocompatible scaffold, osteogenic growth factors such as bone morphogenetic proteins (BMPs), and stem cells. Yet, the clinical use of BMPs faces challenges such as high cost because of the high quantities of BMP required, the difficulties to retain BMP in situ, and a robust post-operative inflammatory response (Selvig et al, 2002;Smucker et al, 2006;Dickerman et al, 2007).…”

Aplicabilidade de rhBMP-2 em diferentes técnicas de enxertia

“…Quando se associa a BMP com um carreador, propicia-se imobilidade da proteína na área, diminui-se a quantidade de BMP necessária e o tempo para que ocorra a indução 45 . Dentre os materiais testados em associação à BMP, ressaltamos: hidroxiapatita 35,46 ; esponjas de colágeno reabsorvível 16,21,25,35,[46][47][48] ; politetrafluoretileno expandido 49,50 ; osso bovino 16,21,[51][52][53][54] e osso autógeno 55 . Os carreadores mais utilizados são a hidroxiapatita e o colágeno, pois são compostos presentes na estrutura óssea, absorvendo naturalmente a BMP 56 .…”

Periodontal Ligament Stem Cells

“…Many reports have demonstrated the promotion of alveolar bone and cementum regeneration by BMP-2 in several experimental periodontal defects (Kinoshita et al, 1997). Unfortunately, BMP-2 treatment did not induce the formation of functional PDL structures, such as Sharpey's fibers, and sometimes elicited ankylosis (Selvig et al, 2002). Osteogenic protein-1 (OP-1/BMP-7) promoted ALP activity and osteocalcin expression in PDL cells (Dereka et al, 2009).…”