Bone repair: New developments in growth factor delivery systems and their mathematical modeling

Lauzon, Marc-Antoine; Bergeron, Éric; Marcos, Bernard; Faucheux, Nathalie

doi:10.1016/j.jconrel.2012.07.041

Cited by 53 publications

(30 citation statements)

References 124 publications

(271 reference statements)

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“…20 Theoretical modeling Existing literatures offer various kinds of mathematical (analytical), computational (numerical), and theoretical models of drug release from polymeric microspheres. [21][22][23][24][25] With differ-ent transport phenomena, one can classify these into diffusion-, swelling-, and erosion-based models. 21,23 Because PLGA is a bulk erosion copolymer and its swelling phenomenon is not obvious, not all available models can be applied to PLGA-based drug delivery systems including swellingbased and surface erosion-based models.…”

Section: Theoretical and Computational Modelsmentioning

confidence: 99%

Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories

et al. 2016

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Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact the degradation rates of PLGA polymers and concurrent drug release kinetics. This work is intended to provide a comprehensive and collective review of the physicochemical and physiological factors that dictate the degradation behavior of PLGA polymers and drug release from contemporary PLGA-based drug-polymer products. In conjunction with the existing experimental results, analytical and numerical theories developed to predict drug release from PLGA-based polymers are summarized and correlated with the experimental observations. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1692-1716, 2017.

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Section: Theoretical and Computational Modelsmentioning

confidence: 99%

Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories

et al. 2016

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“…rhBMP-2 helps to grow bones better than any other rhBMP; therefore, it is considerably more widely used clinically. BMPs could promote and accelerate the new bone formation and maturation in the implant-bone interface [53,54]. Therefore, the use of the exogenous BMP bone tissue may improve the local content and the activity of BMP, and improve the implant survival rate after radiotherapy.…”

Section: Strategies For Improving the Survival Rate Of Implants In Irmentioning

confidence: 99%

How to improve the survival rate of implants after radiotherapy for head and neck cancer?

Zheng

Tang

et al. 2014

J Periodontal Implant Sci

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Implants have been widely used in restorative treatment for patients who have undergone head and neck cancer surgery. With the development of combination treatment of head and neck cancer, radiotherapy has been a common means of therapy. However, it could induce various changes in hard and soft tissues and reduce the success and survival rate of the implants. Some research, using either animal models or clinical studies, have shown that certain strategies could be used for improving the survival rate of implants. In this review, we discussed the changes in both hard and soft tissues, which may reduce the survival rate of the implants, and the proposed methods for improving the survival rate of patients after radiotherapy. Graphical Abstract

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“…The KDF release from the hydrogels was studied by applying an affinity‐based kinetic model that considers the drug release as a result of a partitioning between the solvent phase and the hydrogel . The occurrence of the partition effect is determined by a α factor, called partition activity, and may be obtained by

normalα = \frac{F_{normalm normala normalx}}{1 - F_{normalm normala normalx}}

where F max is the maximum fractional releases of the drug and α is defined as the ratio of the concentrations of solute between the solvent and the hydrogel phases.…”

Section: Resultsmentioning

confidence: 99%

Sustained release of potassium diclofenac from a pH‐responsive hydrogel based on gum arabic conjugates into simulated intestinal fluid

Reis

Moia

Sitta

et al. 2015

J of Applied Polymer Sci

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This work describes the preparation, the swelling properties and the potassium diclofenac (KDF) release profile of hydrogels of gum arabic (GA), N′,N′‐dimethylacrylamide, and methacrylic acid. In order to convert GA into a hydrogel, the polysaccharide was vinyl‐modified with glycidyl methacrylate. The hydrogels showed pH‐responsive swelling changes, which were more expressive in the basic environment. Release data of KDF were adjusted to a diffusion‐based kinetic model that provides an important insight on affinity of the drug for hydrogel and solvent, which may be the leading parameter for release of guest molecules from polymers. The KDF release from the hydrogels into simulated intestinal fluid decreases when the amount of modified GA increases. This was demonstrated to be due to the higher affinity of KDF for GA‐richer hydrogel, which makes the anti‐inflammatory release less favorable. The analysis of released drug half‐time (t1/2 = 16.10 and 21.51 h) indicated sustained release characteristics. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43319.

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Bone repair: New developments in growth factor delivery systems and their mathematical modeling

Cited by 53 publications

References 124 publications

Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories

Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories

How to improve the survival rate of implants after radiotherapy for head and neck cancer?

Sustained release of potassium diclofenac from a pH‐responsive hydrogel based on gum arabic conjugates into simulated intestinal fluid

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