AbstractThe musculoskeletal system has an integral role throughout life, including
structural support to the body, protection, and allowing a range of fine to
complex movements for daily living to elite sporting events. At various times,
injuries to the musculoskeletal system occur resulting in varying levels of
impact to the person both acutely and chronically. Specifically, there is a
spectrum of complexity in orthopedic injuries, with some such as common muscle
strains, that while burdensome will have no impact on life-long functional
ability, and others that can result in long lasting disability. Focusing on
extremity injuries, this review highlights: i)the current impact of orthopedic
injuries in sport and daily life; ii) the foundation of bone
and skeletal muscle repair and regeneration; and iii) the disruptions in
regenerative healing due to traumatic orthopedic injuries. This review seeks to
maximize the broad and collective research impact on sport and traumatic
orthopedic injuries in search of promoting ongoing innovation for treatment and
rehabilitation approaches aimed to improve musculoskeletal health throughout
life.