Bone resection, extra-corporal cryotherapy and immediate re-implantation in the treatment of mandibular tumours

Popescu, V; Spirescu, I

doi:10.1016/s0301-0503(80)80068-3

Cited by 21 publications

(4 citation statements)

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“…Frozen bone experimentation was conducted in the 1970s, but the technique was abandoned because of the high failure rate. [28][29][30][31][32][33][34][35] The most frequent cause of failure was rejection as a result of exposure to saliva, infection, or inadequate vascularization. The risk of failure was greater when soft tissues had been extensively removed to achieve oncological radicality.…”

Section: Discussionmentioning

confidence: 99%

“…This alternative utilizes the experience accumulated using free soft-tissue flaps in conjunction with plates. 21,22 Animal studies, [23][24][25][26][27] subsequently confirmed in humans, [28][29][30][31][32][33][34][35][36][37] have shown that removed segments of mandible can be devitalized by freezing and revitalized after reimplantation. That freezing in liquid nitrogen cleanses the tissue of cancer cells has been demonstrated in vitro, in animals, and in clinical studies.…”

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confidence: 99%

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Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps

et al. 2007

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Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow-up of 52 months (36-70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps

et al. 2007

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“…Their results showed a fair success rate of approximately 35% in some nonirradiated beds, but only 15% of the grafts were successful when utilized pri¬ marily in irradiated wounds. Recent reports by Panje and Cutting11 and Cuono and Ariyan14 reveal success rates varying from 50% to 80% in nonirradiated beds.The unreliability of this technique and the many unacceptable donor site defects have made this method unattractive.Accepted for publication April10, 1986. From the Departments of Otolaryngology (Dr Gullane) and Oral and Maxillofacial Surgery (Dr Holmes), University of Toronto.Read in part at the fall meeting of the American Academy of Facial Plastic and Reconstructive Surgery, Atlanta,Oct 18-19, 1985.…”

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confidence: 99%

Mandibular Reconstruction: New Concepts

Gullane¹,

Holmes²

1986

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\The combination of a myocutaneous flap with a three-dimensional bendable reconstruction plate has provided satisfactory results in restoration of mandibular defects following surgical resections in irradiated patients. Twenty-eight patients were treated and prospectively evaluated. Patients requring postoperative irradiation were excluded from this study. Two groups were identified. Group A (N = 23) required a myocutaneous flap to resurface the soft-tissue defect and group B (N = 5) was treated by primary closure. Seventy-three percent (17 of 23) of patients in group A and 60% (three of five) in group B had received presurgical irradiation but required none after surgery. To date, 64% (18) of the patients have maintained their plates for more than one year, half of these for two years or more. Another 21% (6) have had their plates in place more than six months and the remaining 14% (four) less than six months. One plate was lost in an irradiated group B patient.

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“…A taxa média de infecção foi de 15%, semelhante à taxa de 16% de Dong et al, em 1996. Popescu e;Spirescu, 1980, relata 75 % a taxa de infecção, em consenso, Emmings et al, 1971, Marciani et al, 1977, e, Curi et al, 1997 relatam uma taxa de 5,5%.…”

Section: Discussionunclassified

Ação da crioterapia com nitrogênio líquido associada ao enxerto ósseo autógeno em lesões ósseas mandibulares

Radaic¹

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Aos meus pais, José e Julieta, pelo amor, carinho e apoio incondicional em todos os momentos da minha vida. Ao meu querido esposo Gabriel, luz da minha vida, que me orienta nos caminhos tortuosos e me ilumina nos caminhos obscuros, cuja infinita paciência deu novo sentido a minha vida. Ao querido Enzo, amor eternizado... Te amar é fácil, difícil é viver um só dia sem sua alegria de viver! v AGRADECIMENTOS ESPECIAIS

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Bone resection, extra-corporal cryotherapy and immediate re-implantation in the treatment of mandibular tumours

Cited by 21 publications

References 5 publications

Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps

Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps

Mandibular Reconstruction: New Concepts

Ação da crioterapia com nitrogênio líquido associada ao enxerto ósseo autógeno em lesões ósseas mandibulares

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