Bone Resorption in the Elderly

Stewart, R. J. C.; Sheppard, Hilda G.; Preece, R. F.; Exton-Smtth, A. N.

doi:10.1093/ageing/1.1.1-a

Cited by 8 publications

(3 citation statements)

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“…The significance of the original bone mass as one of the important protective or predisposing determinants in the development of severe osteoporosis later in life has been previously emphasized by us (14, 23) and others (11, 28–30). Thus a person with originally thick bones may afford to lose a considerable amount of bone and still have a bone mass well within the normal limits, i.e., have as much bone as another normal person with an originally smaller bone mass (Fig.…”

Section: Discussionmentioning

confidence: 86%

Involutional (Physiologic) Bone Loss in Women and the Feasibility of Preventing Structural Failure*

Meema

1974

J American Geriatrics Society

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One of the most remarkable manifestations of the normal aging process is loss of bone after age 45-50 in apparently normal women. The magnitude of this loss is such that after the age of 80 virtually all women have bone masses that are smaller than those of normal women before the age of 45, i.e., the two populations with respect to bone mass are entirely different. The relationship of such "physiologic" bone loss to structural failure (vertebral compressions, fractured femoral necks) is discussed by comparing the radiologically measured bone mineral mass in the proximal radius in normal women throughout the adult age range with that in a group of 71 women with vertebral compressions and 36 women with femoral-neck fractures. At a time of life when the incidence of structural failure is still low, a critical range of bone mass can be defined in which the abnormality (bone loss) is clearly recognized in the radius. The prevention of further bone loss at this stage should markedly lower the incidence of both the "crushed vertebrae syndrome" and femoral-neck fracture. This approach is particularly appropriate for those geriatric female patients who still enjoy active life, including sports and travel.Radiologic estimates of bone mass by various methods in normal people show similar patterns of bone loss with age in different racial groups, geographic areas, and groups with different dietary backgrounds (1-6). Generally, there is no significant change of bone mass in normal female populations up to age 45-50, but a steady decrease thereafter (Fig. 1). If "normal bone mass" is defined as values within the 95% confidence limit of the bone mass of young adult women, then half of the normal female population at age 67 and virtually all

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Section: Discussionmentioning

confidence: 86%

Involutional (Physiologic) Bone Loss in Women and the Feasibility of Preventing Structural Failure*

Meema

1974

J American Geriatrics Society

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“…These patients either get replacement biomaterials that would reside in the patient's body for a long term (10-20 years) or regenerative biomaterials that would enable the function of the lost tissue andget degraded in several days to months after fulfilling their mission in the body 10 . Furthermore, in elderly people or pregnant women there is osteoclasis [11][12] . Osteoclasis occurs in these people mostly because of lack of minerals and closing this gap by using the supplies from the bone tissue, as well as due to lack of osteoblast formation in their bones to turn on the repair mechanisms later on [11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in elderly people or pregnant women there is osteoclasis [11][12] . Osteoclasis occurs in these people mostly because of lack of minerals and closing this gap by using the supplies from the bone tissue, as well as due to lack of osteoblast formation in their bones to turn on the repair mechanisms later on [11][12] .…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation of macrophages for bone formation

Ayaz¹

2018

Bioorg.Chem.Med.Rep.

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Especially in elderly women osteoporosis leads to decline in the strength of the bone tissue by erosion of its mass. Weakened bone tissue is more prone to breaks. Patients mostly realize this situation after having a bone breakage especially with the wrist and hip fractures. There has not been an effective way of improving this debilitating condition. A new approach aiming to regulate the activities of the immune system cells in order to reverse osteoporosis and push the tissue for the formation of the bone structure gained attention due to its promising potential. In this review, I will be focusing on this approach by regulation of the macrophage activity, the major immune cell type that is involved in the bone formation. Immunomodulation of the macrophages enable formation and healing of the bone tissue in the patients and conducting more studies in this area would certainly improve the quality of the applicable medicines.

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The Diagnostic Value of Bone Biopsies

Byers¹

1977

Metabolic Bone Disease

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Bone Resorption in the Elderly

Cited by 8 publications

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Involutional (Physiologic) Bone Loss in Women and the Feasibility of Preventing Structural Failure*

Involutional (Physiologic) Bone Loss in Women and the Feasibility of Preventing Structural Failure*

Immunomodulation of macrophages for bone formation

The Diagnostic Value of Bone Biopsies

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