Bone response to a novel Ti–Ta–Nb–Zr alloy

Stenlund, Patrik; Omar, Omar; Brohede, Ulrika; Norgren, Susanne; Norlindh, Birgitta; Johansson, Anna; Lausmaa, Jukka; Thomsen, Peter; Palmquist, Anders

doi:10.1016/j.actbio.2015.03.038

Cited by 78 publications

(57 citation statements)

References 43 publications

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“…1(A) and (B)). We also examined the expression of these ER stress hall markers in mouse L929 cells [21][22][23]. Again, CoPs markedly increased the expression of these proteins in a time-dependent manner (Fig.…”

Section: Activation Of Er Stress In Fibroblasts By Wear Particlesmentioning

confidence: 98%

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

et al. 2015

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Section: Activation Of Er Stress In Fibroblasts By Wear Particlesmentioning

confidence: 98%

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

et al. 2015

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“…It also has a high surface energy and wettability, increasing the likelihood of effective cell attachment and distribution [178] . Numerous studies have shown increased bone-forming behavior on Ta containing surfaces as opposed to plain Ti surfaces [177][178][179][180] .…”

Section: Refractory Ion Containing Coatingsmentioning

confidence: 99%

Additive Manufacturing of Titanium Alloys for Orthopedic Applications: A Materials Science Viewpoint

et al. 2018

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Titanium‐based orthopedic implants are increasingly being fabricated using additive manufacturing (AM) processes such as selective laser melting (SLM), direct laser deposition (DLD), and electron beam melting (EBM). These techniques have the potential to not only produce implants with properties comparable to conventionally manufactured implants, but also improve on standard implant models. These models can be customized for individual patients using medical data, and design features, such as latticing, hierarchical scaffolds, or features to complement patient anatomy, can be added using AM to produce highly functional patient‐anatomy‐specific implants. Alloying prospects made possible through AM allow for the production of Ti‐based parts with compositions designed to reduce modulus and stress shielding while improving bone fixation and formation. The design‐to‐process lead time can be drastically shortened using AM and associated post‐processing, making possible the production of tailored implants for individual patients. This review examines the process and product characteristics of the three major metallic AM techniques and assesses the potential for these in the increased global uptake of AM in orthopedic implant fabrication.

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“…Considering the biocompatibility and the stability of β phase, β stabilizers such as Mo, Ta, Nb, Hf, Pd and Fe are usually selected as primary additive elements in the design of a β-type biomedical Ti alloy. Moreover, Zr can be used as a β stabilizer when used with combination of other β stabilizers such as Ta and Nb, and improve the performance of the Ti alloys202122232425. In this study, Ta, Zr and Hf were selected as the β stabilizers in order to achieve improved performance of the Ti alloys.…”

mentioning

confidence: 99%

Novel Ti-Ta-Hf-Zr alloys with promising mechanical properties for prospective stent applications

Lin

Ozan

et al. 2016

Sci Rep

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Titanium alloys are receiving increasing research interest for the development of metallic stent materials due to their excellent biocompatibility, corrosion resistance, non-magnetism and radiopacity. In this study, a new series of Ti-Ta-Hf-Zr (TTHZ) alloys including Ti-37Ta-26Hf-13Zr, Ti-40Ta-22Hf-11.7Zr and Ti-45Ta-18.4Hf-10Zr (wt.%) were designed using the d-electron theory combined with electron to atom ratio (e/a) and molybdenum equivalence (Moeq) approaches. The microstructure of the TTHZ alloys were investigated using optical microscopy, XRD, SEM and TEM and the mechanical properties were tested using a Vickers micro-indenter, compression and tensile testing machines. The cytocompatibility of the alloys was assessed using osteoblast-like cells in vitro. The as-cast TTHZ alloys consisted of primarily β and ω nanoparticles and their tensile strength, yield strength, Young’s modulus and elastic admissible strain were measured as being between 1000.7–1172.8 MPa, 1000.7–1132.2 MPa, 71.7–79.1 GPa and 1.32–1.58%, respectively. The compressive yield strength of the as-cast alloys ranged from 1137.0 to 1158.0 MPa. The TTHZ alloys exhibited excellent cytocompatibility as indicated by their high cell viability ratios, which were close to that of CP-Ti. The TTHZ alloys can be anticipated to be promising metallic stent materials by virtue of the unique combination of extraordinarily high elastic admissible strain, high mechanical strength and excellent biocompatibility.

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Bone response to a novel Ti–Ta–Nb–Zr alloy

Cited by 78 publications

References 43 publications

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

Additive Manufacturing of Titanium Alloys for Orthopedic Applications: A Materials Science Viewpoint

Novel Ti-Ta-Hf-Zr alloys with promising mechanical properties for prospective stent applications

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