Bone scan hot spots in a patient with lung cancer: Ischaemic necrosis of bone mimicking metastatic carcinoma

Diffuse lesions secondary to sarcoidosis mimicking widespread metastatic breast cancer: A case report

“…21 Other alternative nonmalignant etiologies of bone lesions include fibrous dysplasia of bone, osteonecrosis, osteitis fibrosa cystica, and Paget's disease of bone, among others, can present with PET-avid lesions on imaging and characteristic laboratory findings including hypercalcemia. 10,[13][14][15]22 Infectious etiologies also need to be ruled out when PET-avid bone lesions are identified as disseminated tuberculosis and multifocal osteomyelitis have both been reported to be mistaken for metastases on PET scan. 12, 16,18 Multiple cutoff values have been proposed to distinguish between benign and malignant origins for increased FDG-avidity.…”

“…In fact, a concurrent diagnosis of sarcoidosis has been described in a case report when additional lesions were identified during initial cancer staging workup, but the additional lesions were subsequently determined to be nonmalignant 21 . Other alternative nonmalignant etiologies of bone lesions include fibrous dysplasia of bone, osteonecrosis, osteitis fibrosa cystica, and Paget's disease of bone, among others, can present with PET‐avid lesions on imaging and characteristic laboratory findings including hypercalcemia 10,13‐15,22 . Infectious etiologies also need to be ruled out when PET‐avid bone lesions are identified as disseminated tuberculosis and multifocal osteomyelitis have both been reported to be mistaken for metastases on PET scan 12,16,18 …”