Bone Sialoprotein Immobilized in Collagen Type I Enhances Angiogenesis In Vitro and In Ovo

Kriegel, Anja; Langendorf, Eva K.; Kottmann, Valentina; Kämmerer, Peer W.; Armbruster, Franz Paul; Wiesmann, Nadine; Baranowski, Andreas; Gercek, Erol; Drees, Philipp; Rommens, Pol Maria; Ritz, Ulrike

doi:10.3390/polym15041007

Cited by 6 publications

(1 citation statement)

References 56 publications

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“…Among these genes, the expression of Ibsp was significantly increased in CCI+FF mice compared to FF mice. BSP, a member of small integrin-binding ligand N-linked glycoproteins (SIBLINGs), is crucial for bone tissue formation, remodeling, and repair [43][44][45][46][47]. Our results on Ibsp expression regulation suggest that BSP contributes to enhanced osteogenesis after combined trauma of TBI and femoral fracture.…”

Section: Bone Formation In the Fractured Femur Is Increased By Concom...mentioning

confidence: 74%

Brain–Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior

Ritter,

Baalmann,

Dolderer

et al. 2024

Biomedicines

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Traumatic brain injury (TBI) and long bone fractures are a common injury pattern in polytrauma patients and modulate each other’s healing process. As only a limited number of studies have investigated both traumatic sites, we tested the hypothesis that brain–bone polytrauma mutually impacts neuro- and osteopathological outcomes. Adult female C57BL/6N mice were subjected to controlled cortical impact (CCI), and/or osteosynthetic stabilized femoral fracture (FF), or sham surgery. Neuromotor and behavioral impairments were assessed by neurological severity score, open field test, rotarod test, and elevated plus maze test. Brain and bone tissues were processed 42 days after trauma. CCI+FF polytrauma mice had increased bone formation as compared to FF mice and increased mRNA expression of bone sialoprotein (BSP). Bone fractures did not aggravate neuropathology or neuroinflammation assessed by cerebral lesion size, hippocampal integrity, astrocyte and microglia activation, and gene expression. Behavioral assessments demonstrated an overall impaired recovery of neuromotor function and persistent abnormalities in anxiety-related behavior in polytrauma mice. This study shows enhanced bone healing, impaired neuromotor recovery and anxiety-like behavior in a brain–bone polytrauma model. However, bone fractures did not aggravate TBI-evoked neuropathology, suggesting the existence of outcome-relevant mechanisms independent of the extent of brain structural damage and neuroinflammation.

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Section: Bone Formation In the Fractured Femur Is Increased By Concom...mentioning

confidence: 74%

Brain–Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior

Ritter,

Baalmann,

Dolderer

et al. 2024

Biomedicines

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Incorporating zinc ion into titanium surface promotes osteogenesis and osteointegration in implantation early phase

Tian,

Zhang,

2023

J Mater Sci: Mater Med

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The objective of this study is to further investigate the feasibility of Zinc–Titanium implant as a potential implantable material in oral application in aspects of osteoblast biocompatibility, osteogenesis and osseointegration ability. First, we used plasma immersion ion implantation and deposition (PIIID) technology to introduce Zinc ion into pure Titanium surface, then we used X-ray photoelectron spectroscopy to analyze the chemical composition of modified surface layer; next, we used in vitro studies including immunological fluorescence assay and western blotting to determine responses between MG-63 osteoblast-like cell and implant. In vivo studies adopted pig model to check the feasibility of Zn–Ti implant. Results showed that in vitro and in vivo were consistent, showing that Zn ion was successfully introduced into Ti surface by PIIID technique. The chemical and physical change on modified plant resulted in the more active expressions of mRNA and protein of Type I collagen in MG-63 cells compared with non-treated implant, and the better integration ability of bones with modified implant. We confirmed the Zn–Ti implant owns the ability in promoting osteogenesis and osteointegration in early phase of implantation and is a qualified candidate in dentistry. The overview of our study can be depicted as follows. Graphical Abstract

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Exogenous bone sialoprotein improves extraction socket healing in Ibsp knockout and wild-type mice

Chavez,

Andras,

Tan

et al. 2025

Bone

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Bone Sialoprotein Immobilized in Collagen Type I Enhances Angiogenesis In Vitro and In Ovo

Cited by 6 publications

References 56 publications

Brain–Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior

Brain–Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior

Incorporating zinc ion into titanium surface promotes osteogenesis and osteointegration in implantation early phase

Exogenous bone sialoprotein improves extraction socket healing in Ibsp knockout and wild-type mice

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