Bone status measured by quantitative ultrasound: a comparison with DXA in Thai children

Srichan, W; Thasanasuwan, Wiyada; Kijboonchoo, Kallaya; Rojroongwasinkul, Nipa; Wimonpeerapattana, Wanphen; Khouw, Ilse

doi:10.1038/ejcn.2015.180

Cited by 12 publications

(11 citation statements)

References 17 publications

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“… 19 However, DXA scan is considered the gold standard for bone mineral status assessments. 46 In a substudy within the observational PHACS cohort which assessed BMC by DXA scan in HIV-exposed uninfected infants aged <5 weeks, lower BMC was observed in infants born to mothers receiving TDF ART compared with those receiving non–TDF ART; however, observational studies are subject to potential unknown confounders and longitudinal data are not available to determine whether this persists or if it has any clinical significance to the growing child no longer exposed to tenofovir. In contrast, the PROMISE trial substudy reported lower BMC in neonates exposed to both TDF-based and zidovudine-based ART compared with those exposed to zidovudine/single-dose nevirapine, but there were not significant differences between BMC when comparing infants exposed to TDF-based ART vs. zidovudine-based ART.…”

Section: Discussionmentioning

confidence: 99%

Safety of Tenofovir Disoproxil Fumarate–Based Antiretroviral Therapy Regimens in Pregnancy for HIV-Infected Women and Their Infants: A Systematic Review and Meta-Analysis

Nachega

Uthman

Mofenson

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Section: Discussionmentioning

confidence: 99%

Safety of Tenofovir Disoproxil Fumarate–Based Antiretroviral Therapy Regimens in Pregnancy for HIV-Infected Women and Their Infants: A Systematic Review and Meta-Analysis

Nachega

Uthman

Mofenson

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…As a major public health problem, osteoporosis is a metabolic skeletal disease where the risk of fragility fracture increases because the bone becomes porous and brittle [1]; it is the most common reason for a broken bone among the elderly [2]. Dual-energy X-ray absorptiometry is considered the gold standard for bone status assessments [3]; however, quantitative ultrasound may be a favorable tool for community-based screening of the high-risk population because it is a cheap, easy-to-access and non-ionizing method [4–6]. One of the quantitative ultrasound parameters is ultrasonic attenuation, which has been reported both in vitro and in vivo [4, 7, 8].…”

Section: Introductionmentioning

confidence: 99%

Influence of cancellous bone microstructure on ultrasonic attenuation: a theoretical prediction

Liu

Zhou

et al. 2019

BioMed Eng OnLine

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BackgroundQuantitative ultrasound has been used for the assessment of cancellous bone status. The attenuation mechanisms of cancellous bone, however, have not been well understood, because the microstructure of cancellous bone is significantly inhomogeneous and the interaction between ultrasound and the microstructure of cancellous bone is complex. In this study, a theoretical approach was applied to investigate the influence of the microstructure of cancellous bone on ultrasonic attenuation.ResultsThe scattering from a trabecular cylinder was significantly angle dependent. The dependencies of the ultrasonic attenuation on frequency, scatterer size, and porosity were explored from the theoretical calculation. Prediction results showed that the ultrasonic attenuation increased with the increase of frequency and decreased linearly with the increase in porosity, and the broadband ultrasound attenuation decreased with the increase in porosity. All these predicted trends were consistent with published experimental data. In addition, our model successfully explained the principle of broadband ultrasound attenuation measurement (i.e., the attenuation over the frequency range 0.3–0.65 MHz was approximately linearly proportional to frequency) by considering the contributions of scattering and absorption to attenuation.ConclusionThe proposed theoretical model may be a potentially valuable tool for understanding the interaction of ultrasound with cancellous bone.

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“…Other studies have reported on determinants of Asian adolescent bone health status using bone ultrasound (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Bone Health Status of Malaysian Pre-adolescent Children in the PREBONE-kids Study

Chang

Arasu

Wong

et al. 2020

Preprint

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Background: Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study). Methods: Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ questionnaire, and serum 25(OH) vitamin D using LC-MS/MS. Results: The mean calcium intake was 348.8 ± 180.1 mg/day and mean serum 25-OH vitamin D level was 43.9 ± 14.5nmol/L. In boys, lean mass (LM) was significantly associated with LSBMC (β = 0.539, p<0.001), LSBMD (β=0.607, p<0.001), TBBMC (β=0.675, p<0.001) and TBBMD (β= 0.481, p<0.01). Height was significantly associated with LSBMC (β =0.346, p<0.001) and TBBMC (β =0.282, p<0.001) while fat mass (FM) (β=0.261, p=0.034) and MET score (β =0.163, p=0.026) were significant predictors of TBBMD. Among girls, LM was significantly associated with LSBMC (β = 0.620, p<0.001), LSBMD (β=0.700, p<0.001), TBBMC (β=0.542, p<0.001) and TBBMD (β= 0.747, p<0.001). Calcium intake was a significant predictor of LSBMC (β=0.102, p=0.034), TBBMC (β=0.122, p<0.001) and TBBMD (β=0.196, p=0.002) in girls. Lean mass (LM) was weakly correlated with MET scores (r = 0.205, p = 0.001) but not protein (r = 0.055, p = 0.393) or energy intake (r = 0.101, p = 0.117). MET score (β = 0.207, p = 0.043) was a significant predictor of LM in boys but no factor was found to predict LM in girls. Conclusion: LM is the major determinant of BMC and BMD among pre-adolescent Malaysian children and physical activity is a significant predictor of LM in boys. Encouraging physical activity, calcium intake and optimum diets that build lean body mass should be the focus for developing public health guidance to ensure optimal bone health status during rapid growth.

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Bone status measured by quantitative ultrasound: a comparison with DXA in Thai children

Abstract: Although QUS is easy and convenient to use, the SOS measurements at the radius seem not appropriate for assessing bone quality status.

Cited by 12 publications

References 17 publications

Safety of Tenofovir Disoproxil Fumarate–Based Antiretroviral Therapy Regimens in Pregnancy for HIV-Infected Women and Their Infants: A Systematic Review and Meta-Analysis

Safety of Tenofovir Disoproxil Fumarate–Based Antiretroviral Therapy Regimens in Pregnancy for HIV-Infected Women and Their Infants: A Systematic Review and Meta-Analysis

Influence of cancellous bone microstructure on ultrasonic attenuation: a theoretical prediction

Factors Associated With Bone Health Status of Malaysian Pre-adolescent Children in the PREBONE-kids Study

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