Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

Crockett, Katie; Arnold, Catherine M.; Farthing, Jonathan P.; Chilibeck, Philip D.; Johnston, James D.; Bath, Brenna; Baxter-Jones, Adam D.G.; Kontulainen, Saija

doi:10.1007/s00198-015-3160-8

Cited by 21 publications

(26 citation statements)

References 39 publications

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“…Yet, we believe an investigation into the impact of handedness on bone in non-athletic individuals is necessary to fully understand the relationship between mechanostat biofeedback and bone modeling. Additionally, this study builds upon other studies that have reported the effect of age and sex on bone characteristics, but failed to investigate laterality (Hasegawa et al 2001;Edwards et al 2013;Szulc et al 2013;Crockett et al 2015). Finally, our use of pQCT to analyze cross-sectional bone provides more detailed data than similar studies only focusing on bone mass density.…”

Section: Discussionmentioning

confidence: 84%

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Laterality and grip strength influence hand bone micro‐architecture in modern humans, an HRpQCT study

et al. 2017

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It is widely hypothesized that mechanical loading, specifically repetitive low-intensity tasks, influences the inner structure of cancellous bone. As such, there is likely a relationship between handedness and bone morphology. The aim of this study is to determine patterns in trabecular bone between dominant and non-dominant hands in modern humans. Seventeen healthy patients between 22 and 32 years old were included in the study. Radial carpal bones (lunate, capitate, scaphoid, trapezium, trapezoid, 1st, 2nd and 3rd metacarpals) were analyzed with high-resolution micro-computed tomography. Additionally, crush and pinch grip were recorded. Factorial analysis indicated that bone volume ratio, trabeculae number (Tb.N), bone surface to volume ratio (BS.BV), body weight, stature and crush grip were all positively correlated with principal components 1 and 2 explaining 78.7% of the variance. Volumetric and trabecular endostructural parameters (BV/TV, BS/BV or Tb.Th, Tb.N) explain the observed inter-individual variability better than anthropometric or clinical parameters. Factors analysis regressions showed correlations between these parameters and the dominant side for crush strength for the lunate (r = 0.640, P < 0.0001), trapezium (r = 0.836, P < 0.0001) and third metacarpal (r = 0.763). However, despite a significant lateralization in grip strength for all patients, the endostructural variability between dominant and non-dominant sides was limited in perspective to inter-individual differences. In conclusion, handedness is unlikely to generate trabecular patterns of asymmetry. It appears, however, that crush strength can be considered for endostructural analysis in the modern human wrist.

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Section: Discussionmentioning

confidence: 84%

“…; Crockett et al. ). Finally, our use of pQCT to analyze cross‐sectional bone provides more detailed data than similar studies only focusing on bone mass density.…”

Section: Discussionmentioning

confidence: 98%

Laterality and grip strength influence hand bone micro‐architecture in modern humans, an HRpQCT study

et al. 2017

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“…Distal fractures, including forearm fractures, were associated with increased mortality risk only in the group who suffered a subsequent fracture in an Australian study. (14) In addition, several factors, such as loss of independence and mobility, limited activities of daily living, (25) or reduced muscle strength, (26) that are associated with forearm fracture are likely to have a detrimental impact on an elderly person's health status. Older women with wrist fracture in the Study of Osteoporotic Fractures were 50% more likely than those without fracture to experience a clinically important functional decline, such as decreased ability to prepare meals, perform heavy housekeeping, climb 10 stairs, go shopping, or get out of a car.…”

Section: Discussionmentioning

confidence: 99%

Population-Wide Impact of Non-Hip Non-Vertebral Fractures on Mortality

Tran

Bliuc

Geel

et al. 2017

Journal of Bone and Mineral Research

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Data on long-term consequences of non-hip non-vertebral (NHNV) fractures, accounting for approximately two-thirds of all fragility fractures, are scanty. Our study aimed to quantify the population-wide impact of NHNV fractures on mortality. The national populationbased prospective cohort study (Canadian Multicentre Osteoporosis Study) included 5526 community dwelling women and 2163 men aged 50 years or older followed from July 1995 to September 2013. Population impact number was used to quantify the average number of people for whom one death would be attributable to fracture and case impact number to quantify the number of deaths out of which one would be attributable to a fracture. There were 1370 fragility fractures followed by 296 deaths in women (mortality rate: 3.49; 95% CI, 3.11 to 3.91), and 302 fractures with 92 deaths in men (5.05; 95% CI, 4.12 to 6.20). NHNV fractures accounted for threequarters of fractures. In women, the population-wide impact of NHNV fractures on mortality was greater than that of hip and vertebral fractures because of the greater number of NHNV fractures. Out of 800 women, one death was estimated to be attributable to a NHNV fracture, compared with one death in 2000 women attributable to hip or vertebral fracture. Similarly, out of 15 deaths in women, one was estimated to be attributable to a NHNV fracture, compared with one in over 40 deaths for hip or vertebral fracture. The impact of forearm fractures (ie, one death in 2400 women and one out of 42 deaths in women attributable to forearm fracture) was similar to that of hip, vertebral, or rib fractures. Similar, albeit not significant, results were noted for men. The study highlights the important contribution of NHNV fractures on mortality because many NHNV fracture types, except for the most distal fractures, have serious adverse consequences that affect a significant proportion of the population.

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“…Low lower-limb skeletal muscle density has been associated with higher risk of fractures in older adults (1)(2)(3)(4)(5). Low muscle density is an indicator of higher amounts of intraand intermuscular adipose tissue (IMAT) and can be assessed at the mid-calf in older adults using peripheral quantitative computed tomography (pQCT) (6).…”

Section: Introductionmentioning

confidence: 99%

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative

Scott

Johansson

McMillan

et al. 2019

Bone

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Highlights • Lower mid-calf muscle density was associated with increased likelihood for multiple incident falls over 12 months • Muscle density was inconsistently associated with bone parameters at the hip, lumbar spine and proximal and distal radius • Muscle density was consistently positively associated with tibial bone parameters suggesting local effects on bone health • Moderate/vigorous physical activity was positively associated with mid-calf muscle

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Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

Abstract: Women with recent DRF had lower pQCT-derived estimated bone strength at the distal radius and tibia and lower muscle density and strength at both extremities.

Cited by 21 publications

References 39 publications

Laterality and grip strength influence hand bone micro‐architecture in modern humans, an HRpQCT study

Laterality and grip strength influence hand bone micro‐architecture in modern humans, an HRpQCT study

Population-Wide Impact of Non-Hip Non-Vertebral Fractures on Mortality

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative

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