Bone strength is related to muscle volume in ambulant individuals with bilateral spastic cerebral palsy

Noble, Jonathan J; Fry, Nicola; Lewis, Alan P.; Keevil, Stephen; Gough, Martin; Shortland, Adam P

doi:10.1016/j.bone.2014.06.028

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…Data in both animal and human models[ 15 , 16 ] have shown that muscle size and fascicle length become smaller in response to disuse and immobilization. This effect on muscle thickness and fascicle length may contribute to muscle weakness and imbalance[ 8 , 11 , 35 , 36 ]. An increasing number of studies have reported that muscle thickness is smaller and fascicle length is shorter in the gastrocnemius muscle in children with spastic CP.…”

Section: Discussionmentioning

confidence: 99%

Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers

Chen

Hé

et al. 2018

PLoS ONE

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ObjectiveTo compare the muscle thickness, fascicle length, and pennation angle of the gastrocnemius, soleus, and tibialis anterior between Asian children with spastic cerebral palsy (CP) and typically developing (TD) peers.MethodsThis cross-sectional study involved a total of 72 children with hemiplegic CP (n = 24), and diplegic CP (n = 24) and their TD peers (n = 24). Muscle architecture was measured at rest using ultrasound. Clinical measures included gross motor function and a modified Ashworth scale.ResultsThe thicknesses of the tibialis anterior and medial gastrocnemius muscles were smaller in the affected calf of children with CP (p<0.05) than in those of their TD peers. Additionally, the lengths of the lateral gastrocnemius and soleus fascicle were shorter (p<0.05) in children with diplegic CP than in their TD peers. The fascicle length was shorter in the affected calf of children with CP (p<0.05) than in the calves of their TD peers or the unaffected calf of children with hemiplegic CP. However, the length of the lateral gastrocnemius fascicle was similar between the two legs of children with hemiplegic CP. The pennation angles of the medial gastrocnemius and soleus muscles were larger (p<0.05) in the affected calf in children with hemiplegic CP than in the calves of their TD peers. The fascicle length of the lateral gastrocnemius and the thickness of the soleus muscle were positively correlated with gross motor function scores in children with CP (p<0.05).ConclusionsMuscle thickness and fascicle length were lower in the affected tibialis anterior, gastrocnemius, and soleus in children with spastic CP. These changes may limit the ability to stand and walk, and indicate a need to strengthen the affected muscle.

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Section: Discussionmentioning

confidence: 99%

Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers

Chen

Hé

et al. 2018

PLoS ONE

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“…All participants (or their guardians if <16y) gave informed consent to take part in this study and the publication of the data. MRI data from eight of the 11 participants have previously been reported in a study investigating the relationship between muscle size and bone strength in individuals with CP …”

Section: Methodsmentioning

confidence: 99%

“…MRI data from eight of the 11 participants have previously been reported in a study investigating the relationship between muscle size and bone strength in individuals with CP. 14…”

Section: Methods Participantsmentioning

confidence: 99%

Selective motor control and gross motor function in bilateral spastic cerebral palsy

Noble

Gough

Shortland

2018

Develop Med Child Neuro

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“…Muscle volume to body mass ratio data from 10 out of 21 of the participants with CP and 10 out of 23 of the TD participants have been previously reported in a study comparing mean lower limb muscle volumes between individuals with CP and their TD peers (Noble et al, 2014).…”

Section: Methodsmentioning

confidence: 89%

“…Many studies have shown that children and adults with cerebral palsy (CP) have smaller muscle volumes normalised to body mass than their typically developing peers (Fry et al, 2007;Malaiya et al, 2007;Barber et al, 2011;Noble et al, 2014;Handsfield et al, 2016). To date, there are few studies investigating longitudinal muscle growth in this patient group.…”

Section: Introductionmentioning

confidence: 99%

Lower limb muscle volume estimation from maximum cross-sectional area and muscle length in cerebral palsy and typically developing individuals

Vanmechelen

Shortland

Noble

2018

Clinical Biomechanics

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Bone strength is related to muscle volume in ambulant individuals with bilateral spastic cerebral palsy

Cited by 18 publications

References 36 publications

Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers

Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers

Selective motor control and gross motor function in bilateral spastic cerebral palsy

Lower limb muscle volume estimation from maximum cross-sectional area and muscle length in cerebral palsy and typically developing individuals

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