Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Jing, Chunlan; Chen, Shen-Mao; Bhatia, Sehajdev Singh; Li, Bowen; Liang, Hongze; Liu, Chaozong; Liang, Zhigang; Liu, Junying; Li, Haiyan; Liu, Ziyu; Tan, Hui; Zhao, Lingling

doi:10.1016/j.polymertesting.2022.107584

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…The relative cell viability was higher than 92% at all experimental conditions, even incubated with a polymer at high concentrations (1000 μg mL –1 ) for 72 h, indicating that both GC-PBA and FA-GC-PBA had no obvious cytotoxicity to HSFs and had good biocompatibility. In addition, polymeric micelles can promote cell proliferation within a certain concentration range, possibly because polymeric micelles can provide more attachment sites for cell growth and accelerate the initial cell proliferation. , However, the difference in the proliferation rate will be weakened with the extension of the incubation time.…”

Section: Resultsmentioning

confidence: 99%

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Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on the cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer drug delivery and specific drug release in tumor tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed for the targeted delivery of doxorubicin (DOX). The drug release profile suggested a sustained drug release from the polymeric micelles and an accelerated drug release at lower pH and higher ROS levels. The cellular uptake assay indicated that the polymeric micelles were internalized by HepG2 cells and that the cellular uptake of micelles can be enhanced by folate modification through a receptor-mediated endocytosis pathway. Furthermore, the folate-modified pH/ ROS dual-responsive polymeric micellar nanocarriers demonstrated enhanced inhibition on the migration of HepG2 cells in the cell scratch test and showed improved suppression on the proliferation of HepG2 cells and a lower IC 50 than the nonfolate micelles in the cell viability test, indicating the desirable in vitro anticancer efficiency of the nanosystem.

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Section: Resultsmentioning

confidence: 99%

“…In addition, polymeric micelles can promote cell proliferation within a certain concentration range, possibly because polymeric micelles can provide more attachment sites for cell growth and accelerate the initial cell proliferation. 35,36 However, the difference in the proliferation rate will be weakened with the extension of the incubation time.…”

Section: 4mentioning

confidence: 99%

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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“…Jing et al [ 64 ] prepared nanoparticles based on PLGA-CS conjugates and PLGA-alendronate (Alen) conjugates. The PLGA-CS combines the good biocompatibility and biodegradability of PLGA and CS, facilitating drug delivery.…”

Section: Synthetic Biodegradable Polymers For Antibacterial Applicationsmentioning

confidence: 99%

Fabrication of Biodegradable and Biocompatible Functional Polymers for Anti-Infection and Augmenting Wound Repair

Deng

Chen

et al. 2022

Polymers

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The problem of bacteria-induced infections threatens the lives of many patients. Meanwhile, the misuse of antibiotics has led to a significant increase in bacterial resistance. There are two main ways to alleviate the issue: one is to introduce antimicrobial agents to medical devices to get local drug releasing and alleviating systemic toxicity and resistance, and the other is to develop new antimicrobial methods to kill bacteria. New antimicrobial methods include cationic polymers, metal ions, hydrophobic structures to prevent bacterial adhesion, photothermal sterilization, new biocides, etc. Biodegradable biocompatible synthetic polymers have been widely used in the medical field. They are often used in tissue engineering scaffolds as well as wound dressings, where bacterial infections in these medical devices can be serious or even fatal. However, such materials usually do not have inherent antimicrobial properties. They can be used as carriers for drug delivery or compounded with other antimicrobial materials to achieve antimicrobial effects. This review focuses on the antimicrobial behavior, preparation methods, and biocompatibility testing of biodegradable biocompatible synthetic polymers. Degradable biocompatible natural polymers with antimicrobial properties are also briefly described. Finally, the medical applications of these polymeric materials are presented.

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“…Recently also the bone-targeted polymeric NPs for ALN delivery based on PLGA conjugated chitosan (CS-PLGA) and alendronate conjugated PLGA (ALN-PLGA) were presented. 57 Both conjugates were obtained employing EDC/NHS chemistry. Developed NPs exhibit sizes in the range of 200–300 nm and reveal sustained ALN release.…”

Section: Nanocarriers For Aln Deliverymentioning

confidence: 99%

How Efficient are Alendronate-Nano/Biomaterial Combinations for Anti-Osteoporosis Therapy? An Evidence-Based Review of the Literature

Klara¹,

Lewandowska-Łańcucka²

2022

IJN

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Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Because of the systemic nature of osteoporosis, the associated escalation in fracture risk affects virtually all skeletal sites. The problem is serious since it is estimated that more than 23 million men and women are at high risk of osteoporotic-like breakages in the European Union. Alendronate (ALN) is the most commonly prescribed oral nitrogen-containing bisphosphonate (BP) for the prevention and the therapy of osteoporosis. This is also one of the most intensely studied drugs in this field. However, ALN is characterized by restricted oral absorption and bioavailability and simultaneously its administration has serious side-effects (jaw osteonecrosis, irritation of the gastrointestinal system, nausea, musculoskeletal pain, and cardiovascular risks). Therefore, delivery systems enabling controlled release and local action of this drug are of great interest, being widely researched and presented in the literature. In this review, we discuss the current trends in the design of various types of alendronate carriers. Our paper is focused on the most recent developments in the field of nano/biomaterials-based systems for ALN delivery, including nano/microformulations, synthetic/natural polymeric and inorganic materials, hydrogel-based materials, scaffolds, coated-like structures, as well as organic–inorganic hybrids. Topics related to the treatment of complex bone diseases including osteoporosis have been covered in several more general reviews; however, the systems for this particular drug have not yet been discussed in detail.

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Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Cited by 8 publications

References 35 publications

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Fabrication of Biodegradable and Biocompatible Functional Polymers for Anti-Infection and Augmenting Wound Repair

How Efficient are Alendronate-Nano/Biomaterial Combinations for Anti-Osteoporosis Therapy? An Evidence-Based Review of the Literature

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