Bone tissue engineering: Scaffold preparation using chitosan and other biomaterials with different design and fabrication techniques

Soundarya, S. Preethi; Menon, A. Haritha; Chandran, S. Viji; Selvamurugan, N.

doi:10.1016/j.ijbiomac.2018.08.056

Cited by 244 publications

(120 citation statements)

References 169 publications

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“…While features of biopolymers such as hydrophilicity, biodegradability, biocompatibility, porosity, and non-toxicity make them attractive materials in many biomedical applications; hydrophobicity combined with biocompatibility and non-toxicity could be determinant in some selected applications where hydrophobicity is a key advantage [140][141][142]. On the other hand, the processing of the polymer and the device's design are equally critical for successful tissue engineering applications [143][144][145][146][147].…”

Section: Biodegradable Polymers As Devices For Tissue Engineeringmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Biodegradable Polymers As Devices For Tissue Engineeringmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…Bone is comprised of four types of cells, namely osteoblasts, osteoclasts, osteocytes and bone lining cells, which dynamically regulate bone homeostasis [106], and is composed of collagen type II (Col II, organic phase) and hydroxyapatite (HA [Ca 10 (PO 4 ) 6 (OH) 2 ], mineral phase; Figure 5) [2,107]. HA has been widely explored and applied in composites for bone regeneration uses given it resembles the natural minerals found in bone, conferring osteoconductivity and structural integrity to the scaffold.…”

Section: Bonementioning

confidence: 99%

“…An ideal scaffold for bone repair/substitution should be (i) flexible, to adapt to any form and space and to be easily arranged into 3D constructs, (ii) its topography and morphology should promote cell adhesion, infiltration and growth and finally (iii) its degradation rate should be proportional to the rate of tissue regeneration, without inducing any toxic or inflammatory responses, in surrounding tissues or the Development of novel scaffold materials that mimic functionally and architecturally the ECM is very important to meet the demands of the advances in bone TE. An ideal scaffold for bone repair/substitution should be (i) flexible, to adapt to any form and space and to be easily arranged into 3D constructs, (ii) its topography and morphology should promote cell adhesion, infiltration and growth and finally (iii) its degradation rate should be proportional to the rate of tissue regeneration, without inducing any toxic or inflammatory responses, in surrounding tissues or the whole host system, by its degradation byproducts [106].…”

Section: Bonementioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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“…Silk fibers are composed of sericin, a glue-like protein that encases and binds fibroin fibers together, and fibroin, which is the core filament responsible for the elasticity of silk [58,60]. Sericin has been reported to cause adverse effects in those with biocompatibility and hypersensitivity to silk [58].…”

Section: Silk-based Materialsmentioning

confidence: 99%

New Resorbable Membrane Materials for Guided Bone Regeneration

2018

Applied Sciences

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Membranes are used for guided bone regeneration (GBR) in bone defects. Resorbable membranes of collagen or aliphatic polyesters that do not require secondary surgery for removal, unlike non-resorbable membranes, have been marketed for GBR. Platelet rich fibrin membrane and silk-based membranes have recently been assessed as membranes for GBR. Studies have been conducted on resorbable membranes with new materials to improve physical properties and bone regeneration without any adverse inflammatory reactions. However, clinical research data remain limited. More studies are needed to commercialize such membranes.

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Bone tissue engineering: Scaffold preparation using chitosan and other biomaterials with different design and fabrication techniques

Cited by 244 publications

References 169 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

New Resorbable Membrane Materials for Guided Bone Regeneration

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