Bone tissue remodeling and development: Focus on matrix metalloproteinase functions

Paiva, Katiúcia Batista Silva; Granjeiro, José Mauro

doi:10.1016/j.abb.2014.07.034

Cited by 162 publications

(152 citation statements)

References 177 publications

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“…The importance of metalloproteinases in the development of the neural-crest-derived craniofacial structures has also been well established [43,57], supporting our attribution of the effect of PhN on craniofacial development to metalloproteinase inhibition. The effects of PhN on angiogenesis are also most parsimoniously explained as the result of metalloproteinase inhibition, as the sprouting, invasive protrusion and pathfinding activities of angioblasts all depend on metalloproteinases [58][59][60][61].…”

Section: Discussionsupporting

confidence: 62%

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development.

Ellis

Crawford

2016

Preprint

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Metalloproteinases are zinc-dependent endopeptidases that function as primary effectors of tissue remodelling, cell-signalling, and many other roles. Their regulation is ferociously complex, and is exquisitely sensitive to their molecular milieu, making in vivo studies challenging. Phenanthroline (PhN) is an inexpensive, broad-spectrum inhibitor of metalloproteinases that functions by chelating the catalytic zinc ion, however its use in vivo has been limited due to suspected off-target effects. PhN is very similar in structure to phenanthrene (Phe), a well-studied poly aromatic hydrocarbon (PAH) known to cause toxicity in aquatic animals by activating the aryl hydrocarbon receptor (AhR). We show that zebrafish are more sensitive to PhN than Phe, and that PhN causes a superset of the effects caused by Phe. Morpholino knock-down of the AhR rescues the effects of PhN that are shared with Phe, suggesting these are due to PAH toxicity. The effects of PhN that are not shared with Phe (specifically disruption of neural crest development and angiogenesis) involve processes known to depend on metalloproteinase activity. Furthermore these PhN-specific effects are not rescued by AhR knock-down, suggesting that these are bona fide effects of metalloproteinase inhibition, and that PhN can be used as a broad spectrum metalloproteinase inhibitor for studies with zebrafish in vivo.

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Section: Discussionsupporting

confidence: 62%

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development.

Ellis

Crawford

2016

Preprint

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“…In this regard, MMPs-2, -3, and -9 proteolytically degrade Ab. 219,230,231,232 Ridnour et al 233 showed that levels of Ab [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] , a product of Ab metabolism by MMP-9, and MMP-9 activity were decreased in brain lysates of hAPPSwDI mice lacking nitric oxide synthase compared to their littermates expressing nitric oxide synthase. Based on these data, the authors concluded that nitric oxide is potentially involved in clearing plaques through increasing MMP-9 activity.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

Rempe

Hartz

Bauer

2016

J Cereb Blood Flow Metab

520

422

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Matrix metalloproteinases are versatile endopeptidases with many different functions in the body in health and disease. In the brain, matrix metalloproteinases are critical for tissue formation, neuronal network remodeling, and blood-brain barrier integrity. Many reviews have been published on matrix metalloproteinases before, most of which focus on the two best studied matrix metalloproteinases, the gelatinases MMP-2 and MMP-9, and their role in one or two diseases. In this review, we provide a broad overview of the role various matrix metalloproteinases play in brain disorders. We summarize and review current knowledge and understanding of matrix metalloproteinases in the brain and at the bloodbrain barrier in neuroinflammation, multiple sclerosis, cerebral aneurysms, stroke, epilepsy, Alzheimer's disease, Parkinson's disease, and brain cancer. We discuss the detrimental effects matrix metalloproteinases can have in these conditions, contributing to blood-brain barrier leakage, neuroinflammation, neurotoxicity, demyelination, tumor angiogenesis, and cancer metastasis. We also discuss the beneficial role matrix metalloproteinases can play in neuroprotection and anti-inflammation. Finally, we address matrix metalloproteinases as potential therapeutic targets. Together, in this comprehensive review, we summarize current understanding and knowledge of matrix metalloproteinases in the brain and at the blood-brain barrier in brain disorders.

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“…Although osteoblasts use certain digestive enzymes to migrate through their environment and remodel their surrounding extracellular matrix, they are generally considered to be tissue-forming, rather than degrading cells (Paiva and Granjeiro, 2014). Therefore, we determine that the main phenomena that we are investigating is that of primary mineralisation, and subsequent changes in the secondary phase of mineralisation are expected to have a very limited input due to the short duration and lack of osteoclasts in the experiment.…”

Section: Introductionmentioning

confidence: 99%

The influence of hydrostatic pressure on tissue engineered bone development

Neßler

Henstock

Haj

et al. 2016

Journal of Theoretical Biology

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The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; i) a component describing the cell memory of the applied stimulation, and ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

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Bone tissue remodeling and development: Focus on matrix metalloproteinase functions

Cited by 162 publications

References 177 publications

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development.

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development.

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

The influence of hydrostatic pressure on tissue engineered bone development

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