Bone tumors: state-of-the-art imaging

Debs, Patrick; Ahlawat, Shivani; Fayad, Laura M.

doi:10.1007/s00256-024-04621-7

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…With the development of medical imaging techniques, the diagnosis of bone lesions is no longer limited to the traditional X-ray, and the role of CT and MRI has become increasingly important ( 3 ). In particular, with the widespread applications of MRI in the bone and joint system, it is now playing an important role in early detection of bone tumor lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Dynamic contrast-enhanced MRI (DCE-MRI) has also been widely explored in bone tumor evaluation based on lesion enhancement pattern, which is shown semi-quantitatively with evaluation of the time intensity curve and quantitatively with pharmacokinetic model determination ( 8 , 9 ). While the use of DWI and/or DCE-MRI for bone tumor evaluation still requires familiarity with potential diagnostic pitfalls due to technical challenges and other confounding biochemical factors, such as the large amount of lipids contained in the bone marrow ( 3 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Preliminary exploration of amide proton transfer weighted imaging in differentiation between benign and malignant bone tumors

Li,

Lin,

Zhang

et al. 2024

Front. Oncol.

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PurposeTo explore the value of 3D amide proton transfer weighted imaging (APTWI) in the differential diagnosis between benign and malignant bone tumors, and to compare the diagnostic performance of APTWI with traditional diffusion-weighted imaging (DWI).Materials and methodsPatients with bone tumors located in the pelvis or lower limbs confirmed by puncture or surgical pathology were collected from January 2021 to July 2023 in the First Affiliated Hospital of Zhengzhou University. All patients underwent APTWI and DWI examinations. The magnetization transfer ratio with asymmetric analysis at the frequency offset of 3.5 ppm [MTRasym(3.5 ppm)] derived by APTWI and the apparent diffusion coefficient (ADC) derived by DWI for the tumors were measured. The Kolmogorou-Smirnou and Levene normality test was used to confirm the normal distribution of imaging parameters; and the independent sample t test was used to compare the differences in MTRasym(3.5 ppm) and ADC between benign and malignant bone tumors. In addition, the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of different imaging parameters in differentiation between benign and malignant bone tumors. P<0.05 means statistically significant.ResultsAmong 85 bone tumor patients, 33 were benign and 52 were malignant. The MTRasym(3.5 ppm) values of malignant bone tumors were significantly higher than those of benign tumors, while the ADC values were significantly lower in benign tumors. ROC analysis shows that MTRasym(3.5 ppm) and ADC values perform well in the differential diagnosis of benign and malignant bone tumors, with the area under the ROC curve (AUC) of 0.798 and 0.780, respectively. Combination of MTRasym(3.5 ppm) and ADC values can further improve the diagnostic performance with the AUC of 0.849 (sensitivity = 84.9% and specificity = 73.1%).ConclusionMTRasym(3.5 ppm) of malignant bone tumors was significantly higher than that of benign bone tumors, reflecting the abnormal increase of protein synthesis in malignant tumors. APTWI combined with DWI can achieve a high diagnostic efficacy in differentiation between benign and malignant bone tumors.

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Section: Introductionmentioning

confidence: 99%