Bone turnover markers, anterior pituitary and gonadal hormones, and bone mass evaluation using quantitative computed tomography in ankylosing spondylitis

Maghraoui, A. El; Tellal, Saida; Chaouir, S.; Lebbar, Khalil; Bezza, A.; Nouijai, A.; Achemlal, L.; Bouhssain, Sanaa; Derouiche, El Mostapha

doi:10.1007/s10067-004-1039-8

Cited by 24 publications

(10 citation statements)

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“…Patients with AS had significant lower serum levels of osteocalcin and higher levels of serum T, LH and PRL (El Maghraoui et al 2005). Recently, we analysed the status of the hypothalamic dopaminergic tone using metoclopramide (MTC) test and the prevalence of pituitary adenomas in SSc.…”

Section: Human Studiesmentioning

confidence: 99%

Immune‐Neuroendocrine Interactions and Autoimmune Diseases

Jara

Navarro

Medina

et al. 2006

Journal of Immunology Research

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The relationship between immune-neuroendocrine system is firmly established. The messengers of this connection are hormones, neuropeptides, neurotransmitters and cytokines. The immune-neuroendocrine system have the capacity to synthesize and release these molecules, which, in turn, can stimulate or suppress the activity of immune or neuroendocrine cells by binding to receptors. In fact, hormones, neuropeptides and neurotransmitters participate in innate and adaptive immune response.Autoimmune rheumatic diseases (ARD) are characterized by aberrant production of pro-inflammatory cytokines, which are a potent activator of the HPA axis. In consequence, high levels of pro-inflammatory hormones such as estrogens and prolactin, and low levels of glucocorticoids, an anti-inflammatory hormone, have been described in the active phase of ARD. In addition, high levels of pro-inflammatory hormones and cytokines have also been frequently detected in organ involvement of patients with ARD, suggesting an abnormal local neuroendocrine immune interaction. There is evidence that hormonal changes may appear before the symptomatic phase of the disease. Therefore, it is possible that a pro-inflammatory hormone favors the rupture of tolerance, which is a key feature of autoimmune diseases. The interactions between the immune-neuroendocrine system have a major impact on our understanding of the pathogenic mechanisms, diagnosis and therapy of ARD.

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Section: Human Studiesmentioning

confidence: 99%

Immune‐Neuroendocrine Interactions and Autoimmune Diseases

Jara

Navarro

Medina

et al. 2006

Journal of Immunology Research

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“…Non-invasive assessment of biochemical bone turnover markers (BTM) may provide more information about the pathophysiology of osteoporosis [14–16]. So far, conflicting data have been published about the relation between BTM, BMD, and disease activity in AS [4, 9, 14, 15, 17–21]. …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, measuring only hip BMD by DXA may not be sufficient to identify all patients with AS-related osteoporosis since bone loss may primarily occur in the spine [23]. Currently, quantitative computed tomography (QCT) is considered to be the best technique to measure spinal BMD in patients with advanced AS, since this technique can measure only trabecular BMD [17, 24, 26]. However, QCT is expensive and has a high radiation dose compared to DXA [27].…”

Section: Introductionmentioning

confidence: 99%

The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients with active disease: a cross-sectional analysis

et al. 2010

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SummaryOsteoporosis is a well recognized complication of ankylosing spondylitis (AS). This study indicates that increased bone turnover, inflammation, and low vitamin D levels are important in the pathophysiology of AS-related osteoporosis, and that bone turnover markers (BTM) are valuable markers to detect bone loss in AS.IntroductionThe aim of this study was to elucidate the pathophysiology of AS-related osteoporosis by investigating the relation between bone mineral density (BMD), BTM, vitamin D, and clinical assessments of disease activity and physical function, as well as to identify parameters that are related to low BMD (osteopenia or osteoporosis) in AS patients with active disease.MethodsOne hundred twenty-eight consecutive Dutch AS outpatients were included in this cross-sectional study. Bath AS Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), C-reactive protein, ASAS-endorsed disease activity score (ASDAS), Bath AS Functional Index (BASFI), bone formation markers procollagen type 1 N-terminal peptide (PINP) and osteocalcin (OC), bone resorption marker serum C-telopeptides of type I collagen (sCTX), 25-hydroxyvitamin D (25OHvitD), lumbar spine and hip BMD, and vertebral fractures were assessed. Z-scores of BTM were calculated using matched 10-year cohorts of a Dutch reference group to correct for the normal influence that age and gender have on bone turnover.ResultssCTX Z-score, OC Z-score, BASDAI, age, and gender were independently related to low BMD. In addition, PINP Z-score, ESR, 25OHvitD, age, and gender were independently related to sCTX and/or OC Z-score.ConclusionsThis study indicates that increased bone turnover, inflammation, and low vitamin D levels are important in the pathophysiology of AS-related osteoporosis. Furthermore, sCTX and OC Z-scores seem to be valuable markers to detect bone loss in AS patients in daily clinical practice where BMD of the lumbar spine, measured by DXA, may be overestimated due to osteoproliferation in patients with advanced AS.

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“…Because SHPT is the most prevalent painful syndrome that affects HD and CKD patients [15], we evaluated mineral metabolism within FS groups. FS has been associated with either high [16] or normal to low [17] bone turnover diseases in non-CKD patients. Patients with higher physical impairment had significantly higher serum PTH levels, but we could not observe any association between severity of FS and serum levels of alkaline phosphatase, calcium, or phosphorus as seen by others [11].…”

Section: Discussionmentioning

confidence: 98%