Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly

Lane, Darius J.R.; Jansson, Patric J.; Richardson, Des R.

doi:10.18632/aging.100966

Cited by 17 publications

(24 citation statements)

References 22 publications

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“…Vitamin C might increase the absorption of dietary iron by up to 10% and calcium decreases iron absorption. Therefore, if both are needed, it is advised to take iron and calcium hours apart [ 69 , 70 ]. Additionally, if taken without food, large doses of iron supplements impair the absorption of zinc [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

2018

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Purpose of ReviewThis review broadly discusses the consequences of inadequate consumption, by deficit or excess, of selected micronutrients on the quality of life and morbidity during aging, specifically considering increases in life expectancy and the costs of care in the older persons.Recent FindingsA literature review of the periods 2012 to 2018, focusing on vitamins A, B12, and D, calcium, iron and folate, was completed as these micronutrients are found to significantly affect the aging process. Causation and application of these micronutrients to disorders related to aging are controversial and mixed. This review highlights research needs and controversial points on the role of these micronutrients.SummaryMicronutrient deficiencies are a common and avoidable contributor to decreased quality of life and healthcare costs in the older persons. Further research is needed to determine adequate intakes and innovative uses, including appropriate thresholds for improved health outcomes for this population.

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Section: Resultsmentioning

confidence: 99%

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

2018

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“…It has long been known that vitamin C enhances iron uptake in the duodenum. However Lane et al (2016) point out that vitamin C is not only increasing dietary iron absorption but also is crucial at cellular level for efficient uptake of iron from transferrin (intracellular reductive mechanism), the only source of iron for erythropoiesis (Lane and Richardson, 2014;Suárez-Ortegón et al, 2016). Whilst vitamin C deficiency is considered to be uncommon, a 2005 publication from the UK found that around 40% of elderly individuals over 65 years of age were vitamin C deficient (Elia and Stratton, 2005).…”

Section: Iron Status and Dietmentioning

confidence: 99%

Iron status in the elderly: A review of recent evidence

Wawer

Jennings

Fairweather‐Tait

2018

Mechanisms of Ageing and Development

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A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, kidney failure, cancer, cardiovascular, and neurodegenerative diseases). Each section of this review concludes with key points from the relevant papers. The overall findings were that disturbed iron metabolism plays a major role in a large number of conditions associated with old age. Correction of iron deficiency/overload may improve disease prognosis, but diagnosis of iron deficiency requires appropriate cut-offs for biomarkers of iron status in elderly men and women to be agreed. Iron deficiency (with or without anemia), anemia of inflammation, and anemia of chronic disease are all widespread in the elderly and, once identified, should be investigated further as they are often indicative of underlying disease. Management options should be reviewed and updated, and novel therapies, which show potential for treating anemia of inflammation or chronic disease, should be considered.

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“…These benefits are particularly helpful as delivery approaches, and time to correct anemia in pregnancy is limited. For iron-deficiency anemia identified in the first or second trimester, there is sufficient time to explore alternatives such as nutrition counseling with dietary modifications, Vitamin C 45,46 and/or treatment of underlying conditions (e.g., H. pylori, pernicious anemia) 32,47 to improve absorption of iron. However, in the third trimester, IV iron expedites resolution of anemia, by repletion of iron stores more quickly.…”

Section: Commentmentioning

confidence: 99%

Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis

Govindappagari

Burwick

2018

Amer J Perinatol

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Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly

Cited by 17 publications

References 22 publications

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Iron status in the elderly: A review of recent evidence

Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis

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