Objective
Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Considering that there are individuals undergoing orthodontic treatment while also using isotretinoin, and that there is limited information on the effects of this combination in the literature, we are proposing this study to evaluate the influence of isotretinoin on OTM.
Materials and Methods
Thirty-five animals were used, and they were randomly divided into 7 groups, containing 5 animals in each group. Group 1: Control; Group 2: OTM for 7 days; Group 3: OTM for 14 days; Group 4: Treated with isotretinoin for 14 days; Group 5: Treated with isotretinoin for 21 days; Group 6: Treated with isotretinoin for 14 days and undergoing OTM for 7 days; Group 7: Treated with isotretinoin for 21 days and undergoing OTM for 14 days. In Groups 6 and 7, the animals were treated with isotretinoin at a dosage of 1.0mg/kg/day for 7 days before OTM and maintained during the movement period in the respective groups.
Results
There was no significant difference on microtomographic parameters [Trabecular Volume (BV/TV), Trabecular Thickness (Tb.Th), Number of Trabeculae (Tb.N) and Trabecular Separation (Tb.Sp)] and tooth displacement between groups.
Conclusion
Isotretinoin did not cause a reduction in tooth displacement during OTM when administered at a dose of 1.0mg/kg/day and isotretinoin did not change the microtomographic parameters of animals treated with isotretinoin + OTM.
