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Creutzig, H.; Schober, O.

doi:10.1007/bf00364738

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“…Another concern is that, brain distribution of IMP changes over time. 3,4 This causes the quality of the perfusion image to degrade by time. The reported data indicate that after one hour post administration, the brain distribution no longer represents perfusion at the time of injection.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and evaluation of99mTc-L, L-ethylenecysteine dimer to assess regional cerebral blood flow

El-Ghany

El-Mohty

Zaghary

et al. 1998

J Radioanal Nucl Chem

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L,L-ethylenecysteine dimer (L,L-ECD) compound was synthesized with an overall yield 31.2% and a melting point 197 198 ~ A systematic study has been carried out on the labelling of L,L-ECD with technetium-99m by ligand exchange via 99mTc-EDTA. The percent labelling yield of L,L-ECD was found _>95% when 0.75, 2.0 mg and 100 ~tg of L,L-ECD, disodium-EDTA and tin (II) were used, respectively, at pH 5.5. The produced 99mTc-L,L-ECD complex is stable, neutral and lipid soluble. The 99mTc-L,L-ECD complex penetrate the blood-brain barrier following intravenous injection in the tail vein of mice with an initial brain uptake equal to 0.9% at 2 minutes and a slow washout equal to 0.65% after 25 minutes. High uptake in the gastrointestinal tract (GIT) was observed. It reaches up to 38.9% at 2 minutes and increased as time pass reaching 48.3% at 60 minutes. These results indicate that this ligand is suitable for brain imaging and has a tendency to be excreted via liver and GIT due to its lipophilicity.

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Section: Introductionmentioning

confidence: 99%