Book Reviews

Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence

“…X-ray Analysis-Compounds 6 and 7 (Table 4 Figure 1) possessed very similar geometrical features: the nitrogen atoms of both structures showed sp2 hybridization that was indicative of a large conjugation of the double bond in the N-C=O moieties. In both structures, the atoms of the seven-membered ring significantly diverted from their least-squares plane, conferring to the ring a barrel-like configuration; the 0 2 and 0 3 carbonyl oxygens and the CI1 methyl carbon went in the opposite direction with respect to the phenyl groups, which formed with the seven-membered ring least-squares planes with angles of 31.9(1)O and 32.8 (2)O in 6 and 27.4(5)' and 48.8 (7)' in 7. Finally, both structures showed a strong intramolecular N1-H...02 hydrogen bond of 2.17(3) and 2.13(3) A for 6 and 7, respectively.…”