2020
DOI: 10.3389/fphys.2020.594151
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Boolean Feedforward Neural Network Modeling of Molecular Regulatory Networks for Cellular State Conversion

Abstract: The molecular regulatory network (MRN) within a cell determines cellular states and transitions between them. Thus, modeling of MRNs is crucial, but this usually requires extensive analysis of time-series measurements, which is extremely difficult to obtain from biological experiments. However, single-cell measurement data such as single-cell RNA-sequencing databases have recently provided a new insight into resolving this problem by ordering thousands of cells in pseudo-time according to their differential ge… Show more

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