Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Abstract

Background: Implant osseointegration is an important of long term success of the widely used Rehabilitation treatment. Many therapeutic presidiums have been investigated to accelerate osseointegration. Concentrated growth factors are third generation platelet concentrate used clinically in acceleration of tissue healing and bone regeneration. The aim of this study was to assess histologically the effect of using CGF on osseointegration of immediate dental implant in animal model Methods: ten animal models (adult mongrel dogs) were selected in this study each to receive one immediate implant of the Spectra system (Inc. Las Vegas, NV 89149, CA. USA). They were divided in to 2 equal groups; group A received immediate implant without CGF as a control group and group B received immediate implant with CGF which was applied to the socket walls before implant placement. Eight weeks postoperatively the animal models were euthanized and implants with surrounding bone were dissected and transferred in formalin to the lab for histologic preparation and histomorphometric analysis Results: histomorphometric analysis revealed the mean percentage of new bone formation for group A (control group) was 25.662 % while for group B it reached 66.939%. Student's t -test revealed that the difference between both groups was statistically significant difference with p value of 0.0001 which indicated the higher amount of bone regeneration in group B indicative of the accelerated osseointegration process in the test group.Conclusion it may be concluded that application of CGF to the socket walls before placement of immediate implant may enhance the healing of bone surrounding implants and accelerate osseointegration providing a convenient and affordable choice for implant placement. Application of this method may, therefore, be effective in enhancing the rate of osseointegration and allow for early loading of immediate implants.